Financiado en parte por Seminis Vegetable Seeds Inc.
Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomised controlled trials
Armah CN, Derdemezis C, Traka MH, Dainty JR, Doleman JF, Saha S, Leung W, Potter JF, Lovegrove JA, Mithen RF
Molecular nutrition & food research · 75 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Technology Strategy Board
- Gobierno
- Biotechnology and Biological Sciences Research Council
- Empresa
- Seminis Vegetable Seeds Inc.
- Subvenciones
- Technology Strategy Board (101119); Biotechnology and Biological Sciences Research Council (BBS/E/F/00044431); Biotechnology and Biological Sciences Research Council (BBS/E/F/00041700); Biotechnology and Biological Sciences Research Council (BBS/E/F/00044431); Biotechnology and Biological Sciences Research Council (BB/J004545/1)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2015-04-07 · Mol Nutr Food Res · vol. 59 · número 5 · págs. 918–926
- Editorial
- Wiley
- Citado
- 106 citas · más que el 92% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities · Pharmacological Effects of Natural Compounds
- Palabras clave
- Glucoraphanin, Ldl cholesterol, Food science, Cholesterol, Chemistry, NAK, Internal medicine, Medicine, Biochemistry, Botany, Biology, Brassica
- MeSH
- humans, brassica, oximes, imidoesters, sulfoxides, glucosinolates, apolipoproteins e, diet, polymorphism, single nucleotide, aged, middle aged, female, male, pten phosphohydrolase, cholesterol, ldl, amp-activated protein kinases, phosphatidylinositol 3-kinases
10 autores
- Charlotte N. Armah🇺🇸🇬🇧Norwich University; Quadram Institute
- Christos S. Derdemezis🇬🇧University of Reading
- Μαρία Τράκα🇺🇸🇬🇧Norwich University; Quadram Institute
- Jack R. Dainty🇺🇸🇬🇧Norwich University; Quadram Institute
- Joanne F. Doleman🇺🇸🇬🇧Norwich University; Quadram Institute
- Shikha Saha🇺🇸🇬🇧Norwich University; Quadram Institute
- W. Leung🇺🇸🇬🇧Norwich University; Quadram Institute
- John F. Potter🇬🇧University of East Anglia
- Julie Anne Lovegrove🇬🇧University of Reading
- Richard F. Mithen🇺🇸🇬🇧 · autor de correspondenciaNorwich University; Quadram Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
Cruciferous-rich diets have been associated with reduction in plasma LDL-cholesterol (LDL-C), which may be due to the action of isothiocyanates derived from glucosinolates that accumulate in these vegetables. This study tests the hypothesis that a diet rich in high glucoraphanin (HG) broccoli will reduce plasma LDL-C.
Methods and results
One hundred and thirty volunteers were recruited to two independent double-blind, randomly allocated parallel dietary intervention studies, and were assigned to consume either 400 g standard broccoli or 400 g HG broccoli per week for 12 weeks. Plasma lipids were quantified before and after the intervention. In study 1 (37 volunteers), the HG broccoli diet reduced plasma LDL-C by 7.1% (95% CI: -1.8%, -12.3%, p = 0.011), whereas standard broccoli reduced LDL-C by 1.8% (95% CI +3.9%, -7.5%, ns). In study 2 (93 volunteers), the HG broccoli diet resulted in a reduction of 5.1% (95% CI: -2.1%, -8.1%, p = 0.001), whereas standard broccoli reduced LDL-C by 2.5% (95% CI: +0.8%, -5.7%, ns). When data from the two studies were combined the reduction in LDL-C by the HG broccoli was significantly greater than standard broccoli (p = 0.031).
Conclusion
Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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