Meta-analysis of the association between vitamin D and autoimmune thyroid disease
Wang J, Lv S, Chen G, Gao C, He J, Zhong H, Xu Y
Nutrients · 131 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-04-03 · Nutrients · vol. 7 · número 4 · págs. 2485–2498
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 232 citas · más que el 95% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Thyroid Disorders and Treatments · Celiac Disease Research and Management
- Palabras clave
- vitamin D, autoimmune thyroid disease, Graves' disease, Hashimoto's thyroiditis, vitamin D deficiency, 25-hydroxyvitamin D, serum vitamin D levels
- MeSH
- humans, vitamin d deficiency, vitamin d, prevalence, graves disease
7 autores
- Jiying Wang🇨🇳Southwest Medical University
- Shishi Lv🇨🇳Southwest Medical University
- Guo Chen🇨🇳Southwest Medical University
- Chenlin Gao🇨🇳Southwest Medical University
- Jianhua He🇨🇳Southwest Medical University
- Haihua Zhong🇨🇳Southwest Medical University
- Yong Jie Xu🇨🇳Southwest Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves' disease (GD) and Hashimoto thyroiditis (HT), is still controversial. The aim was to evaluate the association between vitamin D levels and AITD through systematic literature review. We identified all studies that assessed the association between vitamin D and AITD from PubMed, Embase, CENTRAL, and China National Knowledge Infrastructure (CNKI) databases. We included studies that compared vitamin D levels between AITD cases and controls as well as those that measured the odds of vitamin D deficiency by AITD status. We combined the standardized mean differences (SMD) or the odds ratios (OR) in a random effects model. Twenty case-control studies provided data for a quantitative meta-analysis. Compared to controls, AITD patients had lower levels of 25(OH)D (SMD: -0.99, 95% CI: -1.31, -0.66) and were more likely to be deficient in 25(OH)D (OR 2.99, 95% CI: 1.88, 4.74). Furthermore, subgroup analyses result showed that GD and HT patients also had lower 25(OH)D levels and were more likely to have a 25(OH)D deficiency, suggesting that low levels of serum 25(OH)D was related to AITD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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