Consumption of whole grains and cereal fiber and total and cause-specific mortality: prospective analysis of 367,442 individuals
Huang T, Xu M, Lee A, Cho S, Qi L
BMC medicine · 108 citas
Etiquetas de revisión
Vínculos de autores con la industriaFinanciado por la industriaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NHLBI NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK046200); National Institute of Diabetes and Digestive and Kidney Diseases (DK091718); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK091718); National Heart, Lung, and Blood Institute (R01 HL071981); National Heart, Lung, and Blood Institute (HL-071981); National Institute of Diabetes and Digestive and Kidney Diseases (DK46200.)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-03-23 · BMC Med · vol. 13 · número 1 · pág. 59
- Editorial
- BioMed Central
- Citado
- 182 citas · más que el 100% de estudios similares · 15.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Phytoestrogen effects and research
- Palabras clave
- Medicine, Diabetes mellitus, Prospective cohort study, Cause of death, Disease, Whole grains, Stroke (engine), Mortality rate, Cancer, Internal medicine, Endocrinology, Food science
- MeSH
- humans, cardiovascular diseases, diet, diet surveys, proportional hazards models, prospective studies, dietary fiber, aged, middle aged, female, male, edible grain
5 autores
- Tao Huang🇺🇸Harvard University
- Min Xu🇺🇸Harvard University
- Albert Lee🇺🇸Royal Oak Community Coalition
- Susan Cho
- Lu Qi🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Intakes of whole grains and cereal fiber have been inversely associated with the risk of chronic diseases; however, their relation with total and disease-specific mortality remain unclear. We aimed to prospectively assess the association of whole grains and cereal fiber intake with all causes and cause-specific mortality.
Methods
The study included 367,442 participants from the prospective NIH-AARP Diet and Health Study (enrolled in 1995 and followed through 2009). Participants with cancer, heart disease, stroke, diabetes, and self-reported end-stage renal disease at baseline were excluded.
Results
Over an average of 14 years of follow-up, a total of 46,067 deaths were documented. Consumption of whole grains were inversely associated with risk of all-cause mortality and death from cancer, cardiovascular disease (CVD), diabetes, respiratory disease, infections, and other causes. In multivariable models, as compared with individuals with the lowest intakes, those in the highest intake of whole grains had a 17% (95% CI, 14-19%) lower risk of all-cause mortality and 11-48% lower risk of disease-specific mortality (all P for trend <0.023); those in the highest intake of cereal fiber had a 19% (95% CI, 16-21%) lower risk of all-cause mortality and 15-34% lower risk of disease-specific mortality (all P for trend <0.005). When cereal fiber was further adjusted, the associations of whole grains with death from CVD, respiratory disease and infections became not significant; the associations with all-cause mortality and death from cancer and diabetes were attenuated but remained significant (P for trend <0.029).
Conclusions
Consumption of whole grains and cereal fiber was inversely associated with reduced total and cause-specific mortality. Our data suggest cereal fiber is one potentially protective component.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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