Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain
Volkow ND, Wang GJ, Logan J, Alexoff D, Fowler JS, Thanos PK, Wong C, Casado V, Ferre S, Tomasi D
Translational psychiatry · 109 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Alcohol Abuse and Alcoholism
- Gobierno
- Intramural NIH HHS
Según 3 financiadores declarados.
Publicación
- Publicado
- 2015-04-14 · Transl Psychiatry · vol. 5 · número 4 · pág. e549
- Editorial
- Springer Nature
- Citado
- 166 citas · más que el 99% de estudios similares · 10.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Coffee research and impacts · Adenosine and Purinergic Signaling · Neurotransmitter Receptor Influence on Behavior
- Palabras clave
- Raclopride, Caffeine, Dopamine receptor D2, Adenosine A2A receptor, Striatum, Ventral striatum, Dopamine receptor D3, Internal medicine, Endocrinology, Modafinil, Pharmacology, Dopamine, Receptor, Adenosine receptor, Chemistry, Medicine, Agonist
- MeSH
- brain, neostriatum, caudate nucleus, putamen, humans, raclopride, dopamine, caffeine, receptors, dopamine d2, receptor, adenosine a2a, dopamine antagonists, central nervous system stimulants, positron-emission tomography, affect, arousal, blood pressure, heart rate, adult, middle aged, male, receptors, dopamine d3, ventral striatum
10 autores
- Nora D. Volkow🇺🇸 · autor de correspondenciaNational Institutes of Health; National Institute on Alcohol Abuse and Alcoholism
- G. J. Wang🇺🇸National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism
- Jean Logan🇺🇸Brookhaven National Laboratory
- David Alexoff🇺🇸Brookhaven National Laboratory
- Joanna S. Fowler🇺🇸Brookhaven National Laboratory
- Panayotis K. Thanos🇺🇸Brookhaven National Laboratory
- Christopher Wong🇺🇸National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism
- Vicent Casadó🇪🇸Universitat de Barcelona
- Sergi Ferré🇺🇸National Institute on Drug Abuse
- Dardo G. Tomasi🇺🇸National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caffeine, the most widely consumed psychoactive substance in the world, is used to promote wakefulness and enhance alertness. Like other wake-promoting drugs (stimulants and modafinil), caffeine enhances dopamine (DA) signaling in the brain, which it does predominantly by antagonizing adenosine A2A receptors (A2AR). However, it is unclear if caffeine, at the doses consumed by humans, increases DA release or whether it modulates the functions of postsynaptic DA receptors through its interaction with adenosine receptors, which modulate them. We used positron emission tomography and [(11)C]raclopride (DA D2/D3 receptor radioligand sensitive to endogenous DA) to assess if caffeine increased DA release in striatum in 20 healthy controls. Caffeine (300 mg p.o.) significantly increased the availability of D2/D3 receptors in putamen and ventral striatum, but not in caudate, when compared with placebo. In addition, caffeine-induced increases in D2/D3 receptor availability in the ventral striatum were associated with caffeine-induced increases in alertness. Our findings indicate that in the human brain, caffeine, at doses typically consumed, increases the availability of DA D2/D3 receptors, which indicates that caffeine does not increase DA in the striatum for this would have decreased D2/D3 receptor availability. Instead, we interpret our findings to reflect an increase in D2/D3 receptor levels in striatum with caffeine (or changes in affinity). The association between increases in D2/D3 receptor availability in ventral striatum and alertness suggests that caffeine might enhance arousal, in part, by upregulating D2/D3 receptors.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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