Prospective study of breast cancer in relation to coffee, tea and caffeine in Sweden
Oh JK, Sandin S, Ström P, Löf M, Adami HO, Weiderpass E
International journal of cancer · 49 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Vetenskapsrådet
- Gobierno
- Swedish Research Council
- Subvenciones
- Vetenskapsrådet (K2012–69X-22062–01-3)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2015-04-17 · Int J Cancer · vol. 137 · número 8 · págs. 1979–1989
- Editorial
- Wiley
- Citado
- 71 citas · más que el 96% de estudios similares · 6.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Tea Polyphenols and Effects · Nutritional Studies and Diet
- Palabras clave
- Medicine, Caffeine, Breast cancer, Relative risk, Poisson regression, Confounding, Confidence interval, Prospective cohort study, Lower risk, Incidence (geometry), Cancer, Gynecology, Demography, Internal medicine, Environmental health, Population
- MeSH
- humans, breast neoplasms, caffeine, receptors, estrogen, receptors, progesterone, risk factors, regression analysis, follow-up studies, prospective studies, coffee, tea, adult, middle aged, sweden, female
6 autores
- Jin‐Kyoung Oh🇸🇪🇰🇷Karolinska Institutet; National Cancer Center
- Sven Sandin🇸🇪Karolinska Institutet
- Peter C. Strøm🇸🇪Karolinska Institutet
- Marie Löf🇸🇪Karolinska Institutet
- Hans‐Olov Adami🇺🇸🇸🇪Harvard University; Karolinska Institutet
- Elisabete Weiderpass🇸🇪🇳🇴🇫🇮 · autor de correspondenciaKarolinska Institutet; Cancer Registry of Norway; Folkhälsans Forskningscentrum; UiT The Arctic University of Norway
Resumen
El texto original del estudio, en el idioma en que se publicó.
Studies of coffee and tea consumption and caffeine intake as risk factors for breast cancer are inconclusive. We assessed coffee and tea consumption, caffeine intake, and possible confounding factors among 42,099 women from the Swedish Women's Lifestyle and Health study, the participants of which were aged 30-49 years at enrollment in 1991-1992. Complete follow-up for breast cancer incidence was performed through 2012 via linkage to national registries. Poisson regression models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for breast cancer. During follow-up 1,395 breast cancers were diagnosed. The RR was 0.97 (95% CI 0.94-0.99) for a 1-unit increase in cups of coffee/day, 1.14 (95% CI 1.05-1.24) for a 1-unit increase in cups of tea/day, and 0.97 (95% CI 0.95-1.00) for a 100 mg/day increase in caffeine intake. Although the RR for no consumption (RR = 0.86, 95% CI 0.69-1.08), a group with a relatively small number of women, was not statistically significant, women with higher consumption had a decreased breast cancer risk (3-4 cups/day: RR = 0.87, 95% CI 0.76-1.00; ≥5 cups/day: RR = 0.81, 95% CI 0.70-0.94) compared to women consuming 1-2 cups of coffee/day. Compared to no consumption, women consuming >1 cups tea/day showed an increased breast cancer risk (RR = 1.19, 95% CI 1.00-1.42). Similar patterns of estimates were observed for breast cancer risk overall, during pre- and postmenopausal years, and for ER+ or PR+ breast cancer, but not for ER- and PR- breast cancer. Our findings suggest that coffee consumption and caffeine intake is negatively associated with the risk of overall and ER+/PR- breast cancer, and tea consumption is positively associated with the risk of overall and ER+/PR+ breast cancer.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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