Is dietary nitrate/nitrite exposure a risk factor for development of thyroid abnormality? A systematic review and meta-analysis
Bahadoran Z, Mirmiran P, Ghasemi A, Kabir A, Azizi F, Hadaegh F, Hadaegh F
Nitric oxide : biology and chemistry · 48 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences
- Universidad u hospital
- Research Institute for Endocrine Sciences of Shahid Beheshti University of Medical Sciences
Según 2 financiadores declarados.
Publicación
- Publicado
- 2015-04-17 · Nitric Oxide · vol. 47 · págs. 65–76
- Editorial
- Elsevier BV
- Citado
- 93 citas · más que el 78% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 97 trabajos
- Acceso
- De pago
- Áreas de investigación
- Thyroid Disorders and Treatments · Chemical Analysis and Environmental Impact · Water Treatment and Disinfection
- Palabras clave
- dietary nitrate, dietary nitrite, thyroid cancer, hyperthyroidism, hypothyroidism, thyroid function, inorganic nitrate, thyroid hormones, methemoglobinemia
- MeSH
- thyroid gland, animals, humans, thyroid neoplasms, nitrates, nitrites, diet, risk factors, cross-sectional studies
6 autores
- Zahra Bahadoran🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Parvin Mirmiran🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Asghar Ghasemi🇮🇷 · autor de correspondenciaResearch Institute for Endocrine Sciences; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Ali Kabir🇮🇷Iran University of Medical Sciences; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Fereidoun Azizi🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Farzad Hadaegh🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
The potential effects of inorganic nitrate/nitrite on global health are a much debated issue. In addition to possible methemoglobinemia and carcinogenic properties, anti-thyroid effects of nitrate/nitrite have been suggested. Considering the growing significance of nitrate/nitrite and since there is no comprehensive review in data available, clarifying the effect of nitrate/nitrite on thyroid disorder outcomes is essential. Therefore, we conducted this systematic review of experimental and clinical studies, and a meta-analysis of relevant cohort and cross-sectional studies investigating the association of nitrate/nitrite exposure and thyroid function. Most animal studies show that high exposure (~10-600 times of acceptable daily intake) to nitrate/nitrite induces anti-thyroid effects, including decreased serum level of thyroid hormones and histomorphological changes in thyroid gland; however no similar observations have been documented in humans. Based on our meta-analysis, no significant association was observed between nitrate exposure and the risk of thyroid cancer, hyper- and hypothyroidism; findings from three cohort studies however showed a significant association between higher exposure to nitrite and the risk of thyroid cancer (risk = 1.48, 95% confidence interval = 1.09-2.02, P = 0.012). Additional research is needed to clarify the association between nitrate/nitrite exposures and both thyroid function and cancer.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.