Impact of creatine on muscle performance and phosphagen stores after immobilization
Fransen JC, Zuhl M, Kerksick CM, Cole N, Altobelli S, Kuethe DO, Schneider S
European journal of applied physiology · 3 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-04-17 · Eur J Appl Physiol · vol. 115 · número 9 · págs. 1877–1886
- Editorial
- Springer Science+Business Media
- Citado
- 8 citas · más que el 67% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Muscle Physiology and Disorders · Exercise and Physiological Responses
- Palabras clave
- creatine supplementation, cast immobilization, phosphocreatine, muscle power, muscle fatigue, 31P NMR
- MeSH
- muscle, skeletal, humans, creatine, phosphocreatine, immobilization, physical endurance, muscle contraction, dietary supplements, female, male, muscle strength, young adult
7 autores
- Jeremy C. Fransen🇺🇸 · autor de correspondenciaLoyola University Chicago
- Micah Zuhl🇺🇸Central Michigan University
- Chad M. Kerksick🇺🇸Lindenwood University
- Nathan H. Cole🇺🇸University of New Mexico
- Steve Altobelli🇺🇸New Mexico Resonance
- Dean O. Kuethe🇺🇸New Mexico Resonance
- Suzanne M. Schneider🇺🇸University of New Mexico
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
This study investigated the effect of creatine (CR) supplementation during cast-immobilization to preserve skeletal muscle total work, power and intramuscular phosphocreatine (PCr) kinetics during dynamic exercise.
Methods
Twenty-five active individuals (24 ± 4 years,) performed wrist flexion exercise within a 1.9 Tesla superconducting magnet before and after 1 week of cast-immobilization. An incremental protocol to fatigue and two constant load (CL1 and CL2) exercise bouts were performed. While casted, participants consumed either 20 g day(-1) of CR or a placebo (PLA). (31)P magnetic resonance spectroscopy was used to quantify in vivo intramuscular PCr levels.
Results
No significant group × time interaction effects were found for work or power throughout all exercise bouts. Total work was significantly reduced over time in both groups (p = 0.049) during the incremental exercise bout. Work production in CL1 tended (p = 0.073) to attenuate in the CR group, compared to PLA. No changes were observed in CL2. Baseline PCr significantly decreased with casting in PLA (PRE: 26.6 ± 6.3 vs. POST: 22.5 ± 5.6 mM kg(-1) wet muscle, p = 0.003). No change (p = 0.31) was observed in the CR group. Changes in work production were significantly correlated with changes in resting PCr in CR (r = -0.63, p = 0.021) but not PLA (r = -0.36, p = 0.26) group.
Conclusions
Results suggest decreases in short-term endurance may be due to alternations of PCr status and/or metabolism. More research is needed to fully determine the efficacy of CR supplementation during short-term immobilization.
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