Efficacy and safety of creatine supplementation in juvenile dermatomyositis: A randomized, double-blind, placebo-controlled crossover trial
Solis MY, Hayashi AP, Artioli GG, Roschel H, Sapienza MT, Otaduy MC, De Sã Pinto AL, Silva CA, Sallum AM, Pereira RM, Gualano B
Muscle & nerve · 22 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Federico and Elvia Faggin Foundation
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Fundação do Amparo ̀ Pesquisa do Estado de São Paulo
- Universidad u hospital
- Núcleo de Apoio à Pesquisa “Saúde da Criança e do Adolescente” da USP
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior
- Organización sin fines de lucro
- Federico Foundation
Según 6 financiadores declarados.
Publicación
- Publicado
- 2015-04-21 · Muscle Nerve · vol. 53 · número 1 · págs. 58–66
- Editorial
- Wiley
- Citado
- 37 citas · más que el 82% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Inflammatory Myopathies and Dermatomyositis · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Palabras clave
- Medicine, Creatine, Juvenile dermatomyositis, Crossover study, Creatine Monohydrate, Placebo, Adverse effect, Internal medicine, Creatine kinase, Dermatomyositis, Randomized controlled trial, Phosphocreatine, Physical therapy, Gastroenterology, Pathology
- MeSH
- muscle, skeletal, humans, dermatomyositis, creatine, phosphocreatine, cytokines, magnetic resonance imaging, exercise, magnetic resonance spectroscopy, sensitivity and specificity, cross-over studies, double-blind method, body composition, eating, bone density, quality of life, dietary supplements, adolescent, child, female, male, young adult, visual analog scale, surveys and questionnaires
11 autores
- Marina Yázigi Solis🇧🇷Universidade de São Paulo
- Ana Paula Hayashi🇧🇷Universidade de São Paulo
- Guilherme Giannini Artioli🇧🇷Universidade de São Paulo
- Hamilton Roschel🇧🇷Universidade de São Paulo
- Marcelo Tatit Sapienza🇧🇷Universidade de São Paulo
- Maria Concepción García Otaduy🇧🇷Universidade de São Paulo
- Ana Lúcia de Sá Pinto🇧🇷Universidade de São Paulo
- Clóvis A. Silva🇧🇷Universidade de São Paulo
- Adriana Maluf Elias Sallum🇧🇷Universidade de São Paulo
- Rosa Maria Rodrigues Pereira🇧🇷Universidade de São Paulo
- Bruno Gualano🇧🇷 · autor de correspondenciaUniversidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
It has been suggested that creatine supplementation is safe and effective for treating idiopathic inflammatory myopathies, but no pediatric study has been conducted to date. The objective of this study was to examine the efficacy and safety of creatine supplementation in juvenile dermatomyositis (JDM) patients.
Methods
In this study, JDM patients received placebo or creatine supplementation (0.1 g/kg/day) in a randomized, crossover, double-blind design. Subjects were assessed at baseline and after 12 weeks. The primary outcome was muscle function. Secondary outcomes included body composition, aerobic conditioning, health-related quality of life, and muscle phosphocreatine (PCr) content. Safety was assessed by laboratory parameters and kidney function measurements.
Results
Creatine supplementation did not affect muscle function, intramuscular PCr content, or any other secondary outcome. Kidney function was not affected, and no side effects were reported.
Conclusions
Twelve weeks of creatine supplementation in JDM patients were well-tolerated and free of adverse effects, but treatment did not affect muscle function, intramuscular PCr, or any other parameter.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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