Financiado en parte por General Mills
Plasma alkylresorcinols, biomarkers of whole-grain intake, are not associated with progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease
McKeown NM, Hruby A, Landberg R, Herrington DM, Lichtenstein AH
Public health nutrition · 7 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- General Mills
- Universidad u hospital
- Tufts Medical Center
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (U01 HL 45488)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2015-04-23 · Public Health Nutr · vol. 19 · número 2 · págs. 326–331
- Editorial
- Cambridge University Press
- Citado
- 10 citas · más que el 78% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Bariatric Surgery and Outcomes · Phytoestrogen effects and research
- Palabras clave
- Medicine, Coronary artery disease, Internal medicine, Cardiology, Coronary atherosclerosis, Prospective cohort study, Artery, Endocrinology
- MeSH
- coronary vessels, humans, disease progression, resorcinols, diet, diet surveys, feeding behavior, postmenopause, aged, middle aged, female, atherosclerosis, coronary artery disease, biomarkers, secale, whole grains
5 autores
- Nicola Mary McKeown🇺🇸 · autor de correspondenciaTufts University; Jean Mayer Human Nutrition Research Center on Aging
- Adela Hruby🇺🇸Massachusetts Department of Public Health; Harvard University
- Rikard Landberg🇸🇪Karolinska Institutet; Swedish University of Agricultural Sciences
- David M. Herrington🇺🇸Atrium Health Wake Forest Baptist
- Alice Hinda Lichtenstein🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The objective of the present study was to examine the relationship between plasma alkyresorcinol (AR) concentrations, which are biomarkers of whole-grain intake, and atherosclerotic progression over 3 years in postmenopausal women with coronary artery disease.
Design
Plasma AR concentrations were measured by a validated GC-MS method in fasting plasma samples. Atherosclerosis progression was assessed using change in mean minimal coronary artery diameter (MCAD) and percentage diameter stenosis (%ST), based on mean proximal vessel diameter across up to ten coronary segments. Dietary intake was estimated using a 126-item interviewer-administered FFQ.
Setting
A prospective study of postmenopausal women participating in the Estrogen Replacement and Atherosclerosis trial.
Subjects
For the analysis of plasma AR concentrations and atherosclerotic progression, plasma samples and follow-up data on angiography were available for 182 women.
Results
Mean whole-grain intake was 9·6 (se 0·6) servings per week. After multivariate adjustment, no significant associations were observed between plasma AR concentrations and change in mean MCAD or progression of %ST. Plasma AR concentrations were significantly correlated with dietary whole grains (r=0·35, P<0·001), cereal fibre (r=0·33, P<0·001), bran (r=0·15, P=0·05), total fibre (r=0·22, P=0·003) and legume fibre (r=0·15, P=0·04), but not refined grains, fruit fibre or vegetable fibre.
Conclusions
Plasma AR concentrations were not significantly associated with coronary artery progression over a 3-year period in postmenopausal women with coronary artery disease. A moderate association was observed between plasma AR concentrations and dietary whole grains and cereal fibre, suggesting it may be a useful biomarker in observational studies.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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