Omega-3 supplements for patients in chemotherapy and/or radiotherapy: A systematic review
de Aguiar Pastore Silva J, Emilia de Souza Fabre M, Waitzberg DL
Clinical nutrition (Edinburgh, Scotland) · 106 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-11-16 · Clin Nutr · vol. 34 · número 3 · págs. 359–366
- Editorial
- Elsevier BV
- Citado
- 158 citas · más que el 79% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Clinical Nutrition and Gastroenterology · Nutrition and Health in Aging
- Palabras clave
- omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, dietary supplements, chemotherapy, radiotherapy, body composition, peripheral neuropathy, immune function, oxidative stress, quality of life, cancer patients
- MeSH
- humans, neoplasms, docosahexaenoic acids, eicosapentaenoic acid, treatment outcome, dietary supplements, databases, factual, randomized controlled trials as topic
3 autores
- Juliana de Aguiar Pastore Silva🇧🇷AC Camargo Hospital
- Maria Emília de Souza Fabre
- Dan Linetzky Waitzberg🇧🇷 · autor de correspondenciaUniversidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in vitro and in vivo, used along with anticancer drugs, have improved cancer treatment outcome. Clinical studies have reported positive results with omega-3 supplements in oncologic patients. We summarized only randomized controlled clinical trials involving the administration of DHA and/or EPA during chemotherapy and/or radiotherapy to assess the effects on treatment outcomes.
Methods
We conducted a systematic literature search using specific terms. Of 157 publications, 10 were selected on the basis of their methodological quality, according to the Oxford Quality Scale and the Cochrane Concealment Assessment. Outcome included body weight and composition, peripheral neuropathy, immune, inflammatory and oxidative status, quality of life, and membrane omega-3 fatty acids incorporation.
Results
Treatment regimens included radiotherapy (1), chemotherapy (8), and chemoradiotherapy (1). The number of patients ranged from 11 to 92 and the daily dose of EPA and/or DHA from 600 mg to 3.6 g. For high quality methodology studies only, the combination of omega-3 fatty acids supplements with conventional chemotherapy was beneficial. None of the studies reported a worse outcome for the supplement patients.
Conclusions
There are beneficial effects of omega-3 fatty acids supplements in patients undergoing chemotherapy and/or radiotherapy on different outcomes, being the preservation of body composition the most evident. Some important outcome like decrease tumor size and prolonging patient survival, are not observed.
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