Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis
Huang Z, Chen J, Ma J, Shen B, Pei F, Kraus VB
Osteoarthritis and cartilage · 90 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- China Health Ministry Program
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (P30/AG028716)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2015-04-25 · Osteoarthritis Cartilage · vol. 23 · número 9 · págs. 1437–1444
- Editorial
- Elsevier BV
- Citado
- 135 citas · más que el 71% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Osteoarthritis Treatment and Mechanisms · Musculoskeletal pain and rehabilitation
- Palabras clave
- low-level laser therapy, knee osteoarthritis, analgesia, WOMAC, stiffness, functional outcome, sham laser, treatment efficacy
- MeSH
- humans, osteoarthritis, knee, treatment outcome, low-level light therapy
6 autores
- Zeyu Huang🇺🇸🇨🇳 · autor de correspondenciaDuke University; Sichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University
- Jintong Chen🇨🇳 · autor de correspondenciaSichuan University
- Jun Ma🇨🇳 · autor de correspondenciaSichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University
- Bin Shen🇨🇳 · autor de correspondenciaSichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University
- Fuxing Pei🇨🇳 · autor de correspondenciaSichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University
- Virginia B. Kraus🇺🇸 · autor de correspondenciaDuke University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To investigate the efficacy of low-level laser therapy (LLLT) treatment of knee osteoarthritis (KOA) by a systematic literature search with meta-analyses on selected studies.
Design
MEDLINE, EMBASE, ISI Web of Science and Cochrane Library were systematically searched from January 2000 to November 2014. Included studies were randomized controlled trials (RCTs) written in English that compared LLLT (at least eight treatment sessions) with sham laser in KOA patients. The efficacy effective size was estimated by the standardized mean difference (SMD). Standard fixed or random-effects meta-analysis was used, and inconsistency was evaluated by the I-squared index (I(2)).
Results
Of 612 studies, nine RCTs (seven double-blind, two single-blind, totaling 518 patients) met the criteria for inclusion. Based on seven studies, the SMD in visual analog scale (VAS) pain score right after therapy (RAT) (within 2 weeks after the therapy) was not significantly different between LLLT and control (SMD = -0.28 [95% CI = -0.66, 0.10], I(2) = 66%). No significant difference was identified in studies conforming to the World Association of Laser Therapy (WALT) recommendations (four studies) or on the basis of OA severity. There was no significant difference in the delayed response (12 weeks after end of therapy) between LLLT and control in VAS pain (five studies). Similarly, there was no evidence of LLLT effectiveness based on Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain, stiffness or function outcomes (five and three studies had outcome data right after and 12 weeks after therapy respectively).
Conclusion
Our findings indicate that the best available current evidence does not support the effectiveness of LLLT as a therapy for patients with KOA.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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