A double blind randomized placebo control crossover trial on the effect of dietary nitrate supplementation on exercise tolerance in stable moderate chronic obstructive pulmonary disease
Leong P, Basham JE, Yong T, Chazan A, Finlay P, Barnes S, Bardin PG, Campbell D
BMC pulmonary medicine · 37 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-05-01 · BMC Pulm Med · vol. 15 · número 1 · pág. 52
- Editorial
- BioMed Central
- Citado
- 51 citas · más que el 96% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Chronic Obstructive Pulmonary Disease (COPD) Research · Exercise and Physiological Responses · Nitric Oxide and Endothelin Effects
- Palabras clave
- Medicine, Placebo, Crossover study, COPD, VO2 max, Randomization, Physical therapy, Population, Blood pressure, Randomized controlled trial, Morning, Internal medicine, Heart rate
- MeSH
- humans, beta vulgaris, pulmonary disease, chronic obstructive, nitrates, exercise test, severity of illness index, cross-over studies, double-blind method, oxygen consumption, exercise tolerance, dietary supplements, aged, middle aged, female, male, fruit and vegetable juices
8 autores
- Paul Leong🇦🇺 · autor de correspondenciaMonash Medical Centre; Monash Health
- Jane E Basham🇦🇺Monash Medical Centre; Monash Institute of Medical Research
- Theresa Yong🇦🇺Monash Medical Centre; Monash Health
- Adrian Chazan🇦🇺Monash Medical Centre
- Paul N. Finlay🇦🇺Monash Medical Centre; Monash Health; Monash University
- Sara Laura Barnes🇦🇺Monash Medical Centre; Monash Health; Monash University; Monash Institute of Medical Research
- Phillip G. Bardin🇦🇺Monash Medical Centre; Monash University
- Donald Campbell🇦🇺Monash Medical Centre; Monash Health; Monash University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dietary nitrate supplementation has been shown to decrease the oxygen cost of exercise and prolong exercise tolerance, as measured by sub-maximal exercise endurance distance and time at 85% V̇O2max, in both elite athletes and normal healthy subjects. Patients with chronic obstructive pulmonary disease (COPD) have reduced quality of life and ability to perform activities of daily living attributable to diminished exercise tolerance, and dietary nitrate may be able to ameliorate this.
Methods
We performed a double-blind, computer-randomized placebo control crossover trial at a tertiary Australian hospital to investigate whether dietary nitrate supplementation as beetroot juice (BR) would augment submaximal exercise endurance in individuals with spirometrically confirmed stable moderate COPD. Volunteers underwent an incremental shuttle walk test to determine V̇O2max followed by a test dose of BR to establish safety in the study population. Participants performed an endurance shuttle walk test (ESWT) at 85% V̇O2max after randomization to either a 3 day wash-in of BR (4.8 mmol twice a day) or placebo (nitrate deplete BR), with a final dose on the morning of testing. They then crossed over after 4 day washout. Repeated measures two sided paired t-tests were employed.
Results
35 participants were recruited with 19 completing the trial. In the initial safety phase, we measured systolic blood pressure over four hours post first dose of BR, and found a mean 10 mmHg decrement maximal at 1 hour. One individual developed symptomatic postural hypotension and was excluded. The primary outcomes of ESWT distance and time to fatigue improved by 11% and 6% respectively; however these differences did not achieve statistical significance (p = 0.494 and 0.693 respectively).
Conclusions
Our study does not support a role for routine dietary nitrate supplementation for enhancement of exercise endurance in COPD.
Trial registration
Australia and New Zealand Clinical Trial Register: ACTRN12611001088932.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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