Financiado en parte por GlaxoSmithKline
Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults
Smith GI, Julliand S, Reeds DN, Sinacore DR, Klein S, Mittendorfer B
The American journal of clinical nutrition · 353 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- GlaxoSmithKline
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCATS NIH HHS
- Gobierno
- NIH
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK056341); National Center for Advancing Translational Sciences (UL1-TR-000448); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020579); National Institute of Diabetes and Digestive and Kidney Diseases (DK20579); National Institute of Diabetes and Digestive and Kidney Diseases (DK56341); National Center for Advancing Translational Sciences (KL2 TR000450)); National Center for Advancing Translational Sciences (TR 000450); National Institute of Diabetes and Digestive and Kidney Diseases (P60-DK-020579); National Institutes of Health (UL1‐TR000448); National Institutes of Health (DK20579); National Institutes of Health (DK56341); National Institutes of Health (TR000448)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2015-05-20 · Am J Clin Nutr · vol. 102 · número 1 · págs. 115–122
- Editorial
- Elsevier BV
- Citado
- 506 citas · más que el 100% de estudios similares · 26.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Nutrition and Health in Aging · Muscle metabolism and nutrition
- Palabras clave
- omega-3 fatty acids, fish oil supplementation, sarcopenia, muscle mass, muscle strength, grip strength, isokinetic power, older adults, age-related muscle loss, physical independence
- MeSH
- muscle, skeletal, adipose tissue, erythrocytes, humans, body weight, fatty acids, omega-3, fish oils, hand strength, treatment outcome, activities of daily living, double-blind method, body composition, aged, aged, 80 and over, middle aged, female, male, muscle strength, sarcopenia
6 autores
- Gordon Ian Smith
- Sophie Julliand
- Dominic N. Reeds
- David R. Sinacore🇺🇸Washington University in St. Louis
- Samuel Klein
- Bettina Mittendorfer🇺🇸 · autor de correspondenciaWashington University in St. Louis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Age-associated declines in muscle mass and function are major risk factors for an impaired ability to carry out activities of daily living, falls, prolonged recovery time after hospitalization, and mortality in older adults. New strategies that can slow the age-related loss of muscle mass and function are needed to help older adults maintain adequate performance status to reduce these risks and maintain independence.
Objective
We evaluated the efficacy of fish oil-derived n-3 (ω-3) PUFA therapy to slow the age-associated loss of muscle mass and function.
Design
Sixty healthy 60-85-y-old men and women were randomly assigned to receive n-3 PUFA (n = 40) or corn oil (n = 20) therapy for 6 mo. Thigh muscle volume, handgrip strength, one-repetition maximum (1-RM) lower- and upper-body strength, and average power during isokinetic leg exercises were evaluated before and after treatment.
Results
Forty-four subjects completed the study [29 subjects (73%) in the n-3 PUFA group; 15 subjects (75%) in the control group]. Compared with the control group, 6 mo of n-3 PUFA therapy increased thigh muscle volume (3.6%; 95% CI: 0.2%, 7.0%), handgrip strength (2.3 kg; 95% CI: 0.8, 3.7 kg), and 1-RM muscle strength (4.0%; 95% CI: 0.8%, 7.3%) (all P < 0.05) and tended to increase average isokinetic power (5.6%; 95% CI: -0.6%, 11.7%; P = 0.075).
Conclusion
Fish oil-derived n-3 PUFA therapy slows the normal decline in muscle mass and function in older adults and should be considered a therapeutic approach for preventing sarcopenia and maintaining physical independence in older adults. This study was registered at clinicaltrials.gov as NCT01308957.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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