Palm Oil Consumption Increases LDL Cholesterol Compared with Vegetable Oils Low in Saturated Fat in a Meta-Analysis of Clinical Trials
Sun Y, Neelakantan N, Wu Y, Lote-Oke R, Pan A, van Dam RM
The Journal of nutrition · 87 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Medical Research Council
- Subvenciones
- National Medical Research Council (1270/2010)
Según 1 financiador declarado.
Publicación
- Publicado
- 2015-05-20 · J Nutr · vol. 145 · número 7 · págs. 1549–1558
- Editorial
- Elsevier BV
- Citado
- 159 citas · más que el 81% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 70 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Coconut Research and Applications
- Palabras clave
- palm oil, LDL cholesterol, HDL cholesterol, serum lipids, saturated fat, vegetable oils, trans fatty acids, partially hydrogenated vegetable oils, cooking oil, dietary fat, lipid metabolism, randomized controlled trials, dietary intervention, saturated fat reduction, trans fat reduction, animal fats, triglycerides, fasting insulin, insulin resistance, insulin sensitivity, blood pressure
- MeSH
- humans, dietary fats, fatty acids, trans fatty acids, triglycerides, plant oils, cholesterol, ldl, cholesterol, hdl, randomized controlled trials as topic, palm oil
6 autores
- Ye Ji Sun🇸🇬National University of Singapore; National University Health System
- Nithya Neelakantan🇸🇬National University of Singapore; National University Health System
- Yi Wu🇸🇬National University of Singapore; National University Health System
- Rashmi Lote-Oke🇸🇬National University of Singapore; National University Health System
- An Pan🇸🇬National University of Singapore; National University Health System
- Rob M. van Dam🇺🇸🇸🇬 · autor de correspondenciaHarvard University; National University of Singapore; National University Health System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Palm oil contains a high amount of saturated fat compared with most other vegetable oils, but studies have reported inconsistent effects of palm oil on blood lipids.
Objective
We systematically reviewed the effect of palm oil consumption on blood lipids compared with other cooking oils using data from clinical trials.
Methods
We searched PubMed and the Cochrane Library for trials of at least 2 wk duration that compared the effects of palm oil consumption with any of the predefined comparison oils: vegetable oils low in saturated fat, trans fat-containing partially hydrogenated vegetable oils, and animal fats. Data were pooled by using random-effects meta-analysis.
Results
Palm oil significantly increased LDL cholesterol by 0.24 mmol/L (95% CI: 0.13, 0.35 mmol/L; I(2) = 83.2%) compared with vegetable oils low in saturated fat. This effect was observed in randomized trials (0.31 mmol/L; 95% CI: 0.20, 0.42 mmol/L) but not in nonrandomized trials (0.03 mmol/L; 95% CI: -0.15, 0.20 mmol/L; P-difference = 0.02). Among randomized trials, only modest heterogeneity in study results remained after considering the test oil dose and the comparison oil type (I(2) = 27.5%). Palm oil increased HDL cholesterol by 0.02 mmol/L (95% CI: 0.01, 0.04 mmol/L; I(2) = 49.8%) compared with vegetable oils low in saturated fat and by 0.09 mmol/L (95% CI: 0.06, 0.11 mmol/L; I(2) = 47.8%) compared with trans fat-containing oils.
Conclusions
Palm oil consumption results in higher LDL cholesterol than do vegetable oils low in saturated fat and higher HDL cholesterol than do trans fat-containing oils in humans. The effects of palm oil on blood lipids are as expected on the basis of its high saturated fat content, which supports the reduction in palm oil use by replacement with vegetable oils low in saturated and trans fat. This systematic review was registered with the PROSPERO registry at http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42012002601#.VU3wvSGeDRZ as CRD42012002601.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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