Effects of dietary nitrate supplementation on the oxygen cost of exercise and walking performance in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled crossover trial
Shepherd AI, Gilchrist M, Winyard PG, Jones AM, Hallmann E, Kazimierczak R, Rembialkowska E, Benjamin N, Shore AC, Wilkerson DP
Free radical biology & medicine · 58 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Organización sin fines de lucro
- Diabetes UK
- Universidad u hospital
- NIHR Exeter Clinical Research Facility
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- National Institute for Health and Care Research (CL-2011-23-001)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2015-05-18 · Free Radic Biol Med · vol. 86 · págs. 200–208
- Editorial
- Elsevier BV
- Citado
- 69 citas · más que el 99% de estudios similares · 15.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 73 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects · Exercise and Physiological Responses
- Palabras clave
- nitrate supplementation, beetroot juice, type 2 diabetes, oxygen cost of exercise, walking performance, 6-minute walk test, plasma nitrate, plasma nitrite, pulmonary gas exchange, exercise tolerance
- MeSH
- humans, beta vulgaris, diabetes mellitus, type 2, nitrates, antioxidants, treatment outcome, combined modality therapy, exercise therapy, walking, cross-over studies, double-blind method, oxygen consumption, dietary supplements, aged, middle aged, female, male, fruit and vegetable juices
10 autores
- Anthony I. Shepherd🇬🇧University of Exeter; Royal Devon and Exeter Hospital; NIHR Exeter Clinical Research Facility
- Mark Gilchrist🇬🇧University of Exeter; Royal Devon and Exeter Hospital; NIHR Exeter Clinical Research Facility
- Paul Graham Winyard🇬🇧University of Exeter; Royal Devon and Exeter Hospital; NIHR Exeter Clinical Research Facility
- ANDREW MARK JONES🇬🇧University of Exeter
- Ewelina Hallmann🇵🇱Warsaw University of Life Sciences
- Renata Kazimierczak🇵🇱Warsaw University of Life Sciences
- Ewa Rembiałkowska🇵🇱Warsaw University of Life Sciences
- Nigel Benjamin🇬🇧University of Exeter; Royal Devon and Exeter Hospital; NIHR Exeter Clinical Research Facility
- Angela C. Shore🇬🇧University of Exeter; Royal Devon and Exeter Hospital; NIHR Exeter Clinical Research Facility
- Daryl P. Wilkerson🇬🇧 · autor de correspondenciaUniversity of Exeter
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary nitrate supplementation has been shown to reduce the oxygen (O2) cost of exercise and enhance exercise tolerance in healthy individuals. This study assessed whether similar effects could be observed in individuals with type 2 diabetes (T2DM). In a randomized, double-blind, placebo-controlled crossover study, 48 participants with T2DM supplemented their diet for 4 days with either nitrate-rich beetroot juice (70ml/day, 6.43mmol nitrate/day) or nitrate-depleted beetroot juice as placebo (70ml/day, 0.07mmol nitrate/day). After each intervention period, resting plasma nitrate and nitrite concentrations were measured subsequent to participants completing moderate-paced walking. Pulmonary gas exchange was measured to assess the O2 cost of walking. After a rest period, participants performed the 6-min walk test (6MWT). Relative to placebo, beetroot juice resulted in a significant increase in plasma nitrate (placebo, 57±66 vs beetroot, 319±110µM; P < 0.001) and plasma nitrite concentration (placebo, 680±256 vs beetroot, 1065±607nM; P < 0.001). There were no differences between placebo juice and beetroot juice for the O2 cost of walking (946±221 vs 939±223ml/min, respectively; P = 0.59) and distance covered in the 6MWT (550±83 vs 554±90m, respectively; P = 0.17). Nitrate supplementation did not affect the O2 cost of moderate-paced walking or improve performance in the 6MWT. These findings indicate that dietary nitrate supplementation does not modulate the response to exercise in individuals with T2DM.
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