Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis
Zeng C, Li H, Wei J, Yang T, Deng ZH, Yang Y, Zhang Y, Yang TB, Lei GH
PloS one · 45 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Development and Reform Commission of Hunan Province
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Ministry of Education of the People's Republic of China
- Universidad u hospital
- Central South University
- Gobierno
- Hunan Provincial Innovation Foundation for Postgraduate
- Gobierno
- Fundamental Research Funds for the Central Universities
- Subvenciones
- National Natural Science Foundation of China (No. 81201420, 81272034); National Natural Science Foundation of China (No. 81201420); Hunan Provincial Innovation Foundation for Postgraduate (81472130); Development and Reform Commission of Hunan Province (81472130); Development and Reform Commission of Hunan Province (81272034); National Natural Science Foundation of China (81201420); Central South University (81472130); National Natural Science Foundation of China (81272034); Central South University (81272034); National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130); National Natural Science Foundation of China (14JJ3032); Central South University (14JJ3032); Development and Reform Commission of Hunan Province (14JJ3032); Hunan Provincial Innovation Foundation for Postgraduate (CX2014A005); Hunan Provincial Innovation Foundation for Postgraduate (14JJ3032); Hunan Provincial Innovation Foundation for Postgraduate (81272034); National Natural Science Foundation of China (2013SK2018); National Natural Science Foundation of China (81201420, 81272034, 81472130); National Natural Science Foundation of China (81472130)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-05-26 · PLoS One · vol. 10 · número 5 · pág. e0127666
- Editorial
- Public Library of Science
- Citado
- 71 citas · más que el 94% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Osteoarthritis Treatment and Mechanisms · Parathyroid Disorders and Treatments
- Palabras clave
- Medicine, Osteoarthritis, Odds ratio, Confounding, Confidence interval, Internal medicine, Cross-sectional study, Logistic regression, Pathology
- MeSH
- knee joint, humans, osteoarthritis, knee, disease progression, magnesium, radiography, diet, cross-sectional studies, adult, middle aged, female, male, osteophyte
9 autores
- Chao Zeng🇨🇳Central South University; Xiangya Hospital Central South University
- Hui Li🇨🇳Central South University; Xiangya Hospital Central South University
- Jie Wei🇨🇳Central South University
- Tuo Yang🇨🇳Central South University; Xiangya Hospital Central South University
- Zhenhan Deng🇨🇳Central South University; Xiangya Hospital Central South University
- Ye Seul Yang🇨🇳Central South University; Xiangya Hospital Central South University
- Yi Zhang🇨🇳Central South University; Xiangya Hospital Central South University
- Tu-bao Yang🇨🇳Central South University; Xiangya Hospital Central South University
- Guanghua Lei🇨🇳 · autor de correspondenciaCentral South University; Xiangya Hospital Central South University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the cross-sectional associations between dietary magnesium (Mg) intake and radiographic knee osteoarthritis (OA), joint space narrowing (JSN), and osteophytes (OST) respectively.
Methods
A total of 1626 subjects were included in the study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Radiographic knee OA was defined as Kellgren-Lawrence (K-L) Grade 2 in at least one leg. JSN and OST were assessed individually according to the Osteoarthritis Research Society International (OARSI) atlas. A multivariable logistic analysis model was applied to test the various associations after adjusting for potentially confounding factors.
Results
The relative odds of radiographic knee OA were decreased by 0.53 times in the third quintile of Mg intake [odds ratio (OR) 0.53, 95% confidence interval (CI) 0.28-1.01], 0.40 times in the fourth quintile (OR 0.40, 95% CI 0.17-0.94) and 0.34 times in the fifth quintile (OR 0.34, 95% CI 0.11-1.00) compared with those in the lowest quintile, while P for trend was 0.111. The relative odds of JSN were decreased by 0.49 times in the third quintile of Mg intake (OR 0.49, 95% CI 0.28-0.88) and 0.37 times in the fifth quintile (OR 0.37, 95% CI 0.14-0.98) compared with those in the lowest quintile, while P for trend was 0.088. There was no significant relationship between dietary Mg intake and the presence of OST.
Conclusions
The findings of this cross-sectional study indicate that Mg intake is inversely associated with radiographic knee OA and JSN. It supports potential role of Mg in the prevention of knee OA.
Level of evidence
LevelIII, cross-sectional study.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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