Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation
Wightman EL, Haskell-Ramsay CF, Thompson KG, Blackwell JR, Winyard PG, Forster J, Jones AM, Kennedy DO
Physiology & behavior · 124 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-05-31 · Physiol Behav · vol. 149 · págs. 149–158
- Editorial
- Elsevier BV
- Citado
- 169 citas · más que el 98% de estudios similares · 7.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 74 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Cardiovascular Health and Disease Prevention · Optical Imaging and Spectroscopy Techniques
- Palabras clave
- dietary nitrate, beetroot juice, cerebral blood flow, prefrontal cortex, cognitive performance, nitric oxide, hemodynamics, oxygenated and deoxygenated hemoglobin, task-related brain activation, vegetable consumption, healthy adults
- MeSH
- cerebral cortex, humans, nitrates, hemoglobins, spectroscopy, near-infrared, analysis of variance, cross-sectional studies, double-blind method, affect, cognition, neuropsychological tests, blood pressure, heart rate, dietary supplements, adolescent, adult, female, male, hemodynamics, young adult, fruit and vegetable juices
8 autores
- Emma L. Wightman🇬🇧Northumbria University
- Crystal F. Haskell‐Ramsay🇬🇧Northumbria University
- Kevin Thompson🇬🇧Northumbria University
- Jamie R. Blackwell🇬🇧University of Exeter
- Paul Graham Winyard🇬🇧University of Exeter; Peninsula College of Medicine and Dentistry
- Joanne S. Forster🇬🇧Northumbria University
- ANDREW MARK JONES🇬🇧University of Exeter
- David O. Kennedy🇬🇧 · autor de correspondenciaNorthumbria University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Nitrate derived from vegetables is consumed as part of a normal diet and is reduced endogenously via nitrite to nitric oxide. It has been shown to improve endothelial function, reduce blood pressure and the oxygen cost of sub-maximal exercise, and increase regional perfusion in the brain. The current study assessed the effects of dietary nitrate on cognitive performance and prefrontal cortex cerebral blood-flow (CBF) parameters in healthy adults. In this randomised, double-blind, placebo-controlled, parallel-groups study, 40 healthy adults received either placebo or 450 ml beetroot juice (~5.5 mmol nitrate). Following a 90 minute drink/absorption period, participants performed a selection of cognitive tasks that activate the frontal cortex for 54 min. Near-Infrared Spectroscopy (NIRS) was used to monitor CBF and hemodynamics, as indexed by concentration changes in oxygenated and deoxygenated-haemoglobin, in the frontal cortex throughout. The bioconversion of nitrate to nitrite was confirmed in plasma by ozone-based chemi-luminescence. Dietary nitrate modulated the hemodynamic response to task performance, with an initial increase in CBF at the start of the task period, followed by consistent reductions during the least demanding of the three tasks utilised. Cognitive performance was improved on the serial 3s subtraction task. These results show that single doses of dietary nitrate can modulate the CBF response to task performance and potentially improve cognitive performance, and suggest one possible mechanism by which vegetable consumption may have beneficial effects on brain function.
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