Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis
He C, Lin Z, Robb SW, Ezeamama AE
Nutrients · 154 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-06-08 · Nutrients · vol. 7 · número 6 · págs. 4555–4577
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 242 citas · más que el 94% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 105 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Ovarian function and disorders · Vitamin D Research Studies · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- polycystic ovary syndrome, vitamin D deficiency, serum vitamin D levels, vitamin D supplementation, insulin resistance, dysglycemia, metabolic dysfunction, hormonal dysregulation, HOMA-IR, fasting blood glucose
- MeSH
- humans, polycystic ovary syndrome, insulin resistance, blood glucose, vitamin d, dietary supplements, databases, factual, female, observational studies as topic, metabolic syndrome
4 autores
- Chunla He🇺🇸University of Georgia
- Zhoumeng Lin🇺🇸Kansas State University
- Sara Wagner Robb🇺🇸University of Georgia
- Amara Esther Ezeamama🇺🇸University of Georgia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Vitamin D deficiency (VDD) is common in women with and without polycystic ovary syndrome (PCOS) and may be associated with metabolic and endocrine disorders in PCOS. The aim of this meta-analysis is to assess the associations of serum vitamin D levels with metabolic and endocrine dysregulations in women with PCOS, and to determine effects of vitamin D supplementation on metabolic and hormonal functions in PCOS patients. The literature search was undertaken through five databases until 16 January 2015 for both observational and experimental studies concerning relationships between vitamin D and PCOS. A total of 366 citations were identified, of which 30 were selected (n = 3182). We found that lower serum vitamin D levels were related to metabolic and hormonal disorders in women with PCOS. Specifically, PCOS patients with VDD were more likely to have dysglycemia (e.g., increased levels of fasting glucose and homeostatic model assessment-insulin resistance index (HOMA-IR)) compared to those without VDD. This meta-analysis found no evidence that vitamin D supplementation reduced or mitigated metabolic and hormonal dysregulations in PCOS. VDD may be a comorbid manifestation of PCOS or a minor pathway in PCOS associated metabolic and hormonal dysregulation. Future prospective observational studies and randomized controlled trials with repeated VDD assessment and better characterization of PCOS disease severity at enrollment are needed to clarify whether VDD is a co-determinant of hormonal and metabolic dysregulations in PCOS, represents a consequence of hormonal and metabolic dysregulations in PCOS or both.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.