Caffeine, coffee, and tea intake and urinary estrogens and estrogen metabolites in premenopausal women
Sisti JS, Hankinson SE, Caporaso NE, Gu F, Tamimi RM, Rosner B, Xu X, Ziegler R, Eliassen AH
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 51 citas
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Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Gobierno
- Intramural NIH HHS
- Gobierno
- CCR NIH HHS
- Subvenciones
- National Cancer Institute (R01‐CA050385); National Cancer Institute (T32CA009001); National Cancer Institute (UM1 CA176726); National Cancer Institute (CA67262); National Cancer Institute (HHSN261200800001E)); National Cancer Institute (U01 CA067262); National Cancer Institute (R01‐CA067262); National Cancer Institute (CA50385); National Institutes of Health (HHSN261200800001C); National Cancer Institute (R25-CA098566); National Cancer Institute (T32 CA900137)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2015-06-11 · Cancer Epidemiol Biomarkers Prev · vol. 24 · número 8 · págs. 1174–1183
- Editorial
- American Association for Cancer Research
- Citado
- 63 citas · más que el 96% de estudios similares · 5.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Coffee research and impacts · Cancer Risks and Factors · Tea Polyphenols and Effects
- Palabras clave
- Caffeine, Quartile, Estriol, Luteal phase, Urine, Estrogen, Medicine, Endocrinology, Physiology, Internal medicine, Urinary system, Hormone, Chemistry, Confidence interval
- MeSH
- humans, caffeine, estrogens, chromatography, liquid, cohort studies, prospective studies, premenopause, coffee, tea, adult, middle aged, female, tandem mass spectrometry
9 autores
- Julia S. Sisti🇺🇸 · autor de correspondenciaHarvard University
- Susan E. Hankinson🇺🇸Brigham and Women's Hospital; Harvard University; University of Massachusetts Amherst
- Neil E. Caporaso🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Fangyi Gu🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Rulla M. Tamimi🇺🇸Brigham and Women's Hospital; Harvard University
- BERNARD A. ROSNER🇺🇸Brigham and Women's Hospital
- Xia Xu🇺🇸Leidos (United States)
- Regina G. Ziegler🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- A. Heather Eliassen🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Prior studies have found weak inverse associations between breast cancer and caffeine and coffee intake, possibly mediated through their effects on sex hormones.
Methods
High-performance liquid chromatography/tandem mass spectrometry was used to quantify levels of 15 individual estrogens and estrogen metabolites (EM) among 587 premenopausal women in the Nurses' Health Study II with mid-luteal phase urine samples and caffeine, coffee, and/or tea intakes from self-reported food frequency questionnaires. Multivariate linear mixed models were used to estimate geometric means of individual EM, pathways, and ratios by intake categories, and P values for tests of linear trend.
Results
Compared with women in the lowest quartile of caffeine consumption, those in the top quartile had higher urinary concentrations of 16α-hydroxyestrone (28% difference; Ptrend = 0.01) and 16-epiestriol (13% difference; Ptrend = 0.04), and a decreased parent estrogens/2-, 4-, 16-pathway ratio (Ptrend = 0.03). Coffee intake was associated with higher 2-catechols, including 2-hydroxyestradiol (57% difference, ≥4 cups/day vs. ≤6 cups/week; Ptrend = 0.001) and 2-hydroxyestrone (52% difference; Ptrend = 0.001), and several ratio measures. Decaffeinated coffee was not associated with 2-pathway metabolism, but women in the highest (vs. lowest) category of intake (≥2 cups/day vs. ≤1-3 cups/month) had significantly lower levels of two 16-pathway metabolites, estriol (25% difference; Ptrend = 0.01) and 17-epiestriol (48% difference; Ptrend = 0.0004). Tea intake was positively associated with 17-epiestriol (52% difference; Ptrend = 0.01).
Conclusion
Caffeine and coffee intake were both associated with profiles of estrogen metabolism in premenopausal women.
Impact
Consumption of caffeine and coffee may alter patterns of premenopausal estrogen metabolism.
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