Effect of Low-Energy Diets Differing in Fiber, Red Meat, and Coffee Intake on Cardiac Autonomic Function in Obese Individuals With Type 2 Diabetes
Ziegler D, Strom A, Nowotny B, Zahiragic L, Nowotny PJ, Carstensen-Kirberg M, Herder C, Roden M
Diabetes care · 34 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-06-12 · Diabetes Care · vol. 38 · número 9 · págs. 1750–1757
- Editorial
- American Diabetes Association
- Citado
- 39 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Heart Rate Variability and Autonomic Control · Cardiovascular Syncope and Autonomic Disorders · Vagus Nerve Stimulation Research
- Palabras clave
- Medicine, Internal medicine, Heart rate variability, Diabetes mellitus, Type 2 diabetes, Endocrinology, Cardiac function curve, Insulin resistance, Heart rate, Cardiology, Heart failure, Blood pressure
- MeSH
- autonomic nervous system, humans, diabetes mellitus, type 2, obesity, caloric restriction, energy metabolism, coffee, dietary fiber, adult, middle aged, female, male, red meat
8 autores
- Dan Ziegler🇩🇪 · autor de correspondenciaDeutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
- Alexander Strom🇩🇪Deutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
- Bettina Nowotny🇩🇪Deutsches Diabetes-Zentrum e.V.; Heinrich Heine University Düsseldorf
- Lejla Zahiragic🇩🇪Deutsches Diabetes-Zentrum e.V.; Heinrich Heine University Düsseldorf
- P. Nowotny🇩🇪Deutsches Diabetes-Zentrum e.V.; Heinrich Heine University Düsseldorf
- Maren Carstensen‐Kirberg🇩🇪Deutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
- Christian Herder🇩🇪Deutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
- Michael Roden🇩🇪Deutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The autonomic nervous system (ANS) regulates both the cardiovascular system and energy balance and is disturbed in diabetes and obesity. The effect of different approaches of caloric restriction on ANS function has not been assessed in individuals with diabetes. Thus, we sought to determine whether low-energy diets differing in fiber, red meat, and coffee intake exert differential effects on cardiac autonomic function.
Research design and methods
In this randomized parallel-group pilot trial, obese patients with type 2 diabetes were randomly allocated to consume either a diet high in cereal fiber, free of red meat, and high in coffee (n = 13) or a diet low in fiber, high in red meat, and coffee free (n = 15) over 8 weeks. Eight measures of heart rate variability (HRV) indicating vagal and/or sympathetic modulation over 3 h and inflammatory markers were determined during a hyperinsulinemic-euglycemic clamp.
Results
After 8 weeks, both dietary interventions resulted in a mean weight loss of 5-6 kg, a mean decline in heart rate of 4-6 bpm, and improvement in vagally mediated HRV. However, the changes in HRV parameters from baseline to 8 weeks did not differ between the groups. In the entire study cohort, incremental HRV from baseline to 8 weeks was associated with enhanced oxidative glucose utilization (P < 0.05), but not with insulin sensitivity and inflammatory markers.
Conclusions
In obese patients with type 2 diabetes, energy restriction per se over 8 weeks contributed to improved cardiac vagal function in relation to improved oxidative glucose utilization. This preliminary finding should be verified in a confirmatory trial.
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