Effect of almond consumption on vascular function in patients with coronary artery disease: a randomized, controlled, cross-over trial
Chen CY, Holbrook M, Duess MA, Dohadwala MM, Hamburg NM, Asztalos BF, Milbury PE, Blumberg JB, Vita JA
Nutrition journal · 70 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-06-16 · Nutr J · vol. 14 · número 1 · pág. 61
- Editorial
- BioMed Central
- Citado
- 97 citas · más que el 96% de estudios similares · 5.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Tea Polyphenols and Effects
- Palabras clave
- Medicine, Pulse wave velocity, Randomized controlled trial, Crossover study, Coronary artery disease, Internal medicine, Clinical nutrition, Blood pressure, Reactive hyperemia, Vascular disease, Cardiology, Surgery, Vasodilation, Pathology, Placebo
- MeSH
- humans, nitric oxide, triglycerides, alpha-tocopherol, tumor necrosis factor-alpha, c-reactive protein, e-selectin, vascular cell adhesion molecule-1, interleukin-6, nutrition assessment, cross-over studies, energy intake, nutritional requirements, nutritional status, adult, aged, aged, 80 and over, middle aged, boston, female, male, cholesterol, ldl, cholesterol, hdl, coronary artery disease, young adult, pulse wave analysis, food quality, biomarkers, surveys and questionnaires, prunus dulcis
9 autores
- C‐Y. Oliver Chen🇺🇸 · autor de correspondenciaTufts University; Jean Mayer Human Nutrition Research Center on Aging
- MONIKA M. HOLBROOK🇺🇸Boston University
- Mai‐Ann Duess🇺🇸Boston University
- Mustali M. Dohadwala🇺🇸Boston University
- Naomi M. Hamburg🇺🇸Boston University
- Bela F. Asztalos🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Paul E. Milbury🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Jeffrey B. Blumberg🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Joseph A. Vita🇺🇸Boston University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Almonds reduce cardiovascular disease risk via cholesterol reduction, anti-inflammation, glucoregulation, and antioxidation. The objective of this randomized, controlled, cross-over trial was to determine whether the addition of 85 g almonds daily to a National Cholesterol Education Program (NCEP) Step 1 diet (ALM) for 6 weeks would improve vascular function and inflammation in patients with coronary artery disease (CAD).
Research design and methods
A randomized, controlled, crossover trial was conducted in Boston, MA to test whether as compared to a control NCEP Step 1 diet absent nuts (CON), incorporation of almonds (85 g/day) into the CON diet (ALM) would improve vascular function and inflammation. The study duration was 22 weeks including a 6-weeks run-in period, two 6-weeks intervention phases, and a 4-weeks washout period between the intervention phases. A total of 45 CAD patients (27 F/18 M, 45-77 y, BMI = 20-41 kg/m(2)) completed the study. Drug therapies used by patients were stable throughout the duration of the trial.
Results
The addition of almonds to the CON diet increased plasma α-tocopherol status by a mean of 5.8%, reflecting patient compliance (P ≤0.05). However, the ALM diet did not alter vascular function assessed by measures of flow-mediated dilation, peripheral arterial tonometry, and pulse wave velocity. Further, the ALM diet did not significantly modify the serum lipid profile, blood pressure, C-reactive protein, tumor necrosis factor-α or E-selectin. The ALM diet tended to decrease vascular cell adhesion molecule-1 by 5.3% (P = 0.064) and increase urinary nitric oxide by 17.5% (P = 0.112). The ALM intervention improved the overall quality of the diet by increasing calcium, magnesium, choline, and fiber intakes above the Estimated Average Requirement (EAR) or Recommended Dietary Allowance (RDA).
Conclusions
Thus, the addition of almonds to a NECP Step 1 diet did not significantly impact vascular function, lipid profile or systematic inflammation in CAD patients receiving good medical care and polypharmacy therapies but did improve diet quality without any untoward effect.
Trial registration
The trial was registered with the ClinicalTrials.Gov with the identifier: NCT00782015.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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