Effects of chronic dietary nitrate supplementation on the hemodynamic response to dynamic exercise
Lee JS, Stebbins CL, Jung E, Nho H, Kim JK, Chang MJ, Choi HM
American journal of physiology. Regulatory, integrative and comparative physiology · 45 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Consumo medido con
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Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-06-18 · Am J Physiol Regul Integr Comp Physiol · vol. 309 · número 5 · págs. R459–R466
- Editorial
- American Physiological Society
- Citado
- 56 citas · más que el 99% de estudios similares · 18.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control · Nitric Oxide and Endothelin Effects
- Palabras clave
- Medicine, Brachial artery, Blood pressure, Internal medicine, Dietary Nitrate, Vasodilation, Cardiology, Hemodynamics, Cardiac output, Endocrinology, Nitrate, Chemistry, Nitrite
- MeSH
- muscle, skeletal, endothelium, vascular, humans, beta vulgaris, plant roots, nitrates, exercise, diet, cross-over studies, double-blind method, heart rate, vascular resistance, muscle fatigue, muscle contraction, time factors, bicycling, dietary supplements, male, hemodynamics, young adult, arterial pressure, fruit and vegetable juices
7 autores
- Jae‐Suk Lee🇰🇷Kyung Hee University
- Charles L. Stebbins🇺🇸University of California, Davis
- Eunji Jung🇰🇷Kyung Hee University
- Hosung Nho🇰🇷Kyung Hee University
- Jong Kyung Kim🇰🇷Kyung Hee University
- Myoung‐Jei Chang🇰🇷Kyung Hee University
- Hyun-Min Choi🇰🇷 · autor de correspondenciaKyung Hee University
Resumen
El texto original del estudio, en el idioma en que se publicó.
While acute treatment with beetroot juice (BRJ) containing nitrate (NO3 (-)) can lower systolic blood pressure (SBP), afterload, and myocardial O2 demand during submaximal exercise, effects of chronic supplementation with BRJ (containing a relatively low dose of NO3 (-), 400 mg) on cardiac output (CO), SBP, total peripheral resistance (TPR), and the work of the heart in response to dynamic exercise are not known. Thus, in 14 healthy males (22 ± 1 yr), we compared effects of 15 days of both BRJ and nitrate-depleted beetroot juice (NDBRJ) supplementation on plasma concentrations of NOx (NO3 (-)/NO2 (-)), SBP, diastolic blood pressure (DBP), mean arterial pressure (MAP), CO, TPR, and rate pressure product (RPP) at rest and during progressive cycling exercise. Endothelial function was also assessed via flow-mediated dilation (FMD). BRJ supplementation increased plasma NOx from 83.8 ± 13.8 to 167.6 ± 13.2 μM. Compared with NDBRJ, BRJ reduced SBP, DBP, MAP, and TPR at rest and during exercise (P < 0.05). In addition, RPP was decreased during exercise, while CO was increased, but only at rest and the 30% workload (P < 0.05). BRJ enhanced FMD-induced increases in brachial artery diameter (pre: 12.3 ± 1.6%; post: 17.8 ± 1.9%). We conclude that 1) chronic supplementation with BRJ lowers blood pressure and vascular resistance at rest and during exercise and attenuates RPP during exercise and 2) these effects may be due, in part, to enhanced endothelium-induced vasodilation in contracting skeletal muscle. Findings suggest that BRJ can act as a dietary nutraceutical capable of enhancing O2 delivery and reducing work of the heart, such that exercise can be performed at a given workload for a longer period of time before the onset of fatigue.
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