Increasing Water Intake in Chronic Kidney Disease: Why? Safe? Possible?
Clark WF, Sontrop JM, Moist L, Huang SH
Annals of nutrition & metabolism · 5 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-01-01 · Ann Nutr Metab · vol. 66 · número Suppl. 3 · págs. 18–21
- Editorial
- Karger Publishers
- Citado
- 8 citas · más que el 73% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 11 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Chronic Kidney Disease and Diabetes · Electrolyte and hormonal disorders · Dialysis and Renal Disease Management
- Palabras clave
- chronic kidney disease, vasopressin, urine output, serum sodium, renal function decline, feasibility and safety, pilot study
- MeSH
- humans, disease progression, body weight, sodium, fluid therapy, feasibility studies, pilot projects, sex factors, drinking, osmolar concentration, adult, female, male, renal insufficiency, chronic
4 autores
- William F. Clark🇨🇦London Health Sciences Centre
- Jessica M. Sontrop🇨🇦Western University
- Louise M. MOIST🇨🇦London Health Sciences Centre
- S.-H. Huang🇨🇦London Health Sciences Centre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Increased water intake may slow the progression of chronic kidney disease by lowering vasopressin levels. Prior to initiating a large randomized controlled trial on the effect of increased water intake on renal decline, we conducted a six-week pilot study to examine the safety and feasibility of asking adults with chronic kidney disease to increase their water intake. We randomly assigned 29 patients to either a hydration or a control group. The hydration group was asked to increase water intake by 1 to 1.5 l/day relative to their weight, gender, and 24 h urine osmolality, in addition to usual consumed beverages; the control group was asked to continue with usual fluid intake. After six weeks, the change in urine volume was significantly different between groups (0.9 l/day; p = 0.002) with no change in serum sodium and no serious adverse effects. Similarly, preliminary results of our large clinical trial of the same intervention (489 patients enrolled to date) demonstrated a significant separation between groups on 24 h urine volume (at 12 months the mean difference between groups was 1.2 l/day; p < 0.001) with no serious adverse effects. Serum sodium has remained stable in both groups over follow-up. To our knowledge, this trial is currently the largest of its kind to date; the significant separation between groups with respect to urine volume indicates that we will have scientifically reliable data on the effect of increased fluid intake on renal decline. The analysis of primary and secondary outcomes will be conducted at the conclusion of follow-up in July 2016.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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