Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood
Shirai Y, Fujita Y, Hashimoto R, Ohi K, Yamamori H, Yasuda Y, Ishima T, Suganuma H, Ushida Y, Takeda M, Hashimoto K
PloS one · 69 citas
Etiquetas de revisión
Vínculos de autores con la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Gobierno
- Ministry of Education, Culture, Sports, Science and Technology
- Universidad u hospital
- Chiba University
- Gobierno
- Japan Society for the Promotion of Science
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Ministry of Education, Culture, Sports, Science and Technology (24116006); Japan Society for the Promotion of Science (221S0003); Japan Society for the Promotion of Science (25293250); Japan Society for the Promotion of Science (15K09865)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-06-24 · PLoS One · vol. 10 · número 6 · pág. e0127244
- Editorial
- Public Library of Science
- Citado
- 90 citas · más que el 93% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 68 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Tryptophan and brain disorders · Adenosine and Purinergic Signaling
- Palabras clave
- Sulforaphane, Phencyclidine, Oxidative stress, Cognitive deficit, Prepulse inhibition, Internal medicine, Medicine, Endocrinology, Schizophrenia (object-oriented programming), Pharmacology, Psychiatry, Disease, NMDA receptor, Cognitive impairment, Cancer research
- MeSH
- hippocampus, prefrontal cortex, animals, humans, mice, brassica, disease models, animal, isothiocyanates, sulfoxides, phencyclidine, intracellular signaling peptides and proteins, plant extracts, cognition disorders, schizophrenia, oxidative stress, adolescent, adult, middle aged, child, nf-e2-related factor 2, seedlings, kelch-like ech-associated protein 1
11 autores
- Yumi Shirai🇯🇵Center for Forensic Mental Health, Chiba University
- Yūkō Fujita🇯🇵Center for Forensic Mental Health, Chiba University
- Ryota Hashimoto🇯🇵The University of Osaka
- Kazutaka Ohi🇯🇵The University of Osaka
- Hidenaga Yamamori🇯🇵The University of Osaka
- Yuka Yasuda🇯🇵The University of Osaka
- Tamaki Ishima🇯🇵Center for Forensic Mental Health, Chiba University
- Hiroyuki Suganuma🇯🇵Kagome Co., Ltd. (Japan)
- Yusuke Ushida🇯🇵Kagome Co., Ltd. (Japan)
- Masatoshi Takeda🇯🇵The University of Osaka
- Kenji Hashimoto🇯🇵 · autor de correspondenciaCenter for Forensic Mental Health, Chiba University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Oxidative stress and inflammation play a role in cognitive impairment, which is a core symptom of schizophrenia. Furthermore, a hallmark of the pathophysiology of this disease is the dysfunction of cortical inhibitory γ-aminobutyric acid (GABA) neurons expressing parvalbumin (PV), which is also involved in cognitive impairment. Sulforaphane (SFN), an isothiocyanate derived from broccoli, is a potent activator of the transcription factor Nrf2, which plays a central role in the inducible expressions of many cytoprotective genes in response to oxidative stress. Keap1 is a cytoplasmic protein that is essential for the regulation of Nrf2 activity. Here, we found that pretreatment with SFN attenuated cognitive deficits, the increase in 8-oxo-dG-positive cells, and the decrease in PV-positive cells in the medial prefrontal cortex and hippocampus after repeated administration of phencyclidine (PCP). Furthermore, PCP-induced cognitive deficits were improved by the subsequent subchronic administration of SFN. Interestingly, the dietary intake of glucoraphanin (a glucosinolate precursor of SFN) during the juvenile and adolescence prevented the onset of PCP-induced cognitive deficits as well as the increase in 8-oxo-dG-positive cells and the decrease in PV-positive cells in the brain at adulthood. Moreover, the NRF2 gene and the KEAP1 gene had an epistatic effect on cognitive impairment (e.g., working memory and processing speed) in patients with schizophrenia. These findings suggest that SFN may have prophylactic and therapeutic effects on cognitive impairment in schizophrenia. Therefore, the dietary intake of SFN-rich broccoli sprouts during the juvenile and adolescence may prevent the onset of psychosis at adulthood.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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