Financiado en parte por American Egg Board, Egg Nutrition Center
Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis
Berger S, Raman G, Vishwanathan R, Jacques PF, Johnson EJ
The American journal of clinical nutrition · 233 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Gobierno
- USDA
- Grupo de la industria
- American Egg Board, Egg Nutrition Center
- Subvenciones
- U.S. Department of Agriculture (1950-51000-073)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2015-06-25 · Am J Clin Nutr · vol. 102 · número 2 · págs. 276–294
- Editorial
- Elsevier BV
- Citado
- 356 citas · más que el 99% de estudios similares · 6.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 72 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Nutritional Studies and Diet · Cholesterol and Lipid Metabolism
- Palabras clave
- dietary cholesterol, cardiovascular disease, coronary artery disease, ischemic stroke, hemorrhagic stroke, serum cholesterol, LDL cholesterol, HDL cholesterol, LDL/HDL ratio, triglycerides, VLDL, cholesterol intake, dietary intervention trials, cohort studies, heterogeneity of study results, saturated fat, dietary fiber
- MeSH
- humans, brain ischemia, cardiovascular diseases, hemorrhagic disorders, cholesterol, cholesterol, dietary, risk factors, reproducibility of results, evidence-based medicine, cholesterol, ldl, cholesterol, hdl, coronary artery disease, randomized controlled trials as topic, stroke, non-randomized controlled trials as topic
5 autores
- Samantha E. Berger🇺🇸Tufts Medical Center
- Gowri Raman🇺🇸Tufts Medical Center
- Rohini Vishwanathan🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Paul F. Jacques🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Elizabeth J. Johnson🇺🇸 · autor de correspondenciaTufts University; Jean Mayer Human Nutrition Research Center on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dietary cholesterol has been suggested to increase the risk of cardiovascular disease (CVD), which has led to US recommendations to reduce cholesterol intake.
Objective
The authors examine the effects of dietary cholesterol on CVD risk in healthy adults by using systematic review and meta-analysis.
Design
MEDLINE, Cochrane Central, and Commonwealth Agricultural Bureau Abstracts databases were searched through December 2013 for prospective studies that quantified dietary cholesterol. Investigators independently screened citations and verified extracted data on study and participant characteristics, outcomes, and quality. Random-effect models meta-analysis was used when at least 3 studies reported the same CVD outcome.
Results
Forty studies (17 cohorts in 19 publications with 361,923 subjects and 19 trials in 21 publications with 632 subjects) published between 1979 and 2013 were eligible for review. Dietary cholesterol was not statistically significantly associated with any coronary artery disease (4 cohorts; no summary RR), ischemic stroke (4 cohorts; summary RR: 1.13; 95% CI: 0.99, 1.28), or hemorrhagic stroke (3 cohorts; summary RR: 1.09; 95% CI: 0.79, 1.50). Dietary cholesterol statistically significantly increased both serum total cholesterol (17 trials; net change: 11.2 mg/dL; 95% CI: 6.4, 15.9) and low-density lipoprotein (LDL) cholesterol (14 trials; net change: 6.7 mg/dL; 95% CI: 1.7, 11.7 mg/dL). Increases in LDL cholesterol were no longer statistically significant when intervention doses exceeded 900 mg/d. Dietary cholesterol also statistically significantly increased serum high-density lipoprotein cholesterol (13 trials; net change: 3.2 mg/dL; 95% CI: 0.9, 9.7 mg/dL) and the LDL to high-density lipoprotein ratio (5 trials; net change: 0.2; 95% CI: 0.0, 0.3). Dietary cholesterol did not statistically significantly change serum triglycerides or very-low-density lipoprotein concentrations.
Conclusion
Reviewed studies were heterogeneous and lacked the methodologic rigor to draw any conclusions regarding the effects of dietary cholesterol on CVD risk. Carefully adjusted and well-conducted cohort studies would be useful to identify the relative effects of dietary cholesterol on CVD risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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