Health effects of intermittent fasting: hormesis or harm? A systematic review
Horne BD, Muhlestein JB, Anderson JL
The American journal of clinical nutrition · 146 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- internal institutional funds
Según 1 financiador declarado.
Publicación
- Publicado
- 2015-07-02 · Am J Clin Nutr · vol. 102 · número 2 · págs. 464–470
- Editorial
- Elsevier BV
- Citado
- 240 citas · más que el 90% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 57 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Diet and metabolism studies
- Palabras clave
- intermittent fasting, alternate-day fasting, hormesis, health effects of fasting, weight loss, cholesterol, coronary artery disease, diabetes mellitus, surrogate endpoints
- MeSH
- animals, humans, diabetes mellitus, type 2, hypercholesterolemia, obesity, caloric restriction, diet fads, diet, reducing, fasting, risk factors, evidence-based medicine, health status, adult, overweight, coronary artery disease, randomized controlled trials as topic, hormesis, observational studies as topic, cognitive dysfunction
3 autores
- Benjamin Davies Horne🇺🇸 · autor de correspondenciaIntermountain Healthcare; Intermountain Medical Center
- Joseph Brent Muhlestein🇺🇸Intermountain Healthcare; University of Utah; Intermountain Medical Center
- Jeffrey L. Anderson🇺🇸Intermountain Healthcare; University of Utah; Intermountain Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Intermittent fasting, alternate-day fasting, and other forms of periodic caloric desistance are gaining popularity in the lay press and among animal research scientists. Whether clinical evidence exists for or is strong enough to support the use of such dietary regimens as health interventions is unclear.
Objective
This review sought to identify rigorous, clinically relevant research studies that provide high-quality evidence that therapeutic fasting regimens are clinically beneficial to humans.
Design
A systematic review of the published literature through January 2015 was performed by using sensitive search strategies to identify randomized controlled clinical trials that evaluated the effects of fasting on either clinically relevant surrogate outcomes (e.g., weight, cholesterol) or actual clinical event endpoints [e.g., diabetes, coronary artery disease (CAD)] and any other studies that evaluated the effects of fasting on clinical event outcomes.
Results
Three randomized controlled clinical trials of fasting in humans were identified, and the results were published in 5 articles, all of which evaluated the effects of fasting on surrogate outcomes. Improvements in weight and other risk-related outcomes were found in the 3 trials. Two observational clinical outcomes studies in humans were found in which fasting was associated with a lower prevalence of CAD or diabetes diagnosis. No randomized controlled trials of fasting for clinical outcomes were identified.
Conclusions
Clinical research studies of fasting with robust designs and high levels of clinical evidence are sparse in the literature. Whereas the few randomized controlled trials and observational clinical outcomes studies support the existence of a health benefit from fasting, substantial further research in humans is needed before the use of fasting as a health intervention can be recommended.
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