The Impact of Low-Level Laser Therapy on Oral Mucositis and Quality of Life in Patients Undergoing Hematopoietic Stem Cell Transplantation Using the Oral Health Impact Profile and the Functional Assessment of Cancer Therapy-Bone Marrow Transplantation Questionnaires
Silva LC, Sacono NT, Freire Mdo C, Costa LR, Batista AC, Silva GB
Photomedicine and laser surgery · 20 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-07-01 · Photomed Laser Surg · vol. 33 · número 7 · págs. 357–363
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 34 citas · más que el 82% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, oral mucositis, hematopoietic stem cell transplantation, quality of life, chemotherapy-induced mucositis, Oral Health Impact Profile, FACT-BMT, high-dose chemotherapy
- MeSH
- humans, leukemia, lymphoma, stomatitis, hematopoietic stem cell transplantation, double-blind method, quality of life, adolescent, adult, middle aged, oral health, female, male, young adult, surveys and questionnaires, low-level light therapy
6 autores
- Lorrany Candido Silva🇧🇷Universidade Federal de Goiás
- Nancy Tomoko Sacono🇧🇷Universidade Federal de Goiás
- Maria do Carmo Matias Freire🇧🇷Universidade Federal de Goiás
- Luciane Rezende Costa🇧🇷Universidade Federal de Goiás
- Aline Carvalho Batista🇧🇷Universidade Federal de Goiás
- Geisa Badauy Lauria Silva🇧🇷 · autor de correspondenciaHospital Araújo Jorge
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The aim of this study was to assess the impact of low-level laser therapy (LLLT) on oral mucositis (OM) and quality of life (QoL) of hematopoietic stem cell transplantation (HSCT) patients.
Background data
OM related to high-dose chemotherapy is often associated with increased risk of mortality and impaired QoL in HSCT patients. LLLT has shown promising effects in the prevention and treatment of chemotherapy-induced OM. There is a dearth of literature focused on subjective aspects involving OM and QoL in patients receiving LLLT.
Methods
Thirty-nine patients were randomly assigned to two groups: control (n=19) and laser (n=20). LLLT was performed from the 1st day of the conditioning regimen until day 7 post-HSCT (D+7). OM severity was evaluated in all patients [World Health Organization (WHO) scale]. A blinded observer collected subjective outcomes from patients on admission (AD), D+7 and at discharge (DC). QoL was assessed using the Oral Health Impact Profile (OHIP-14) and the Functional Assessment of Cancer Therapy-Bone Marrow Transplantation (FACT-BMT) questionnaires. Statistical analyses included descriptive, bivariate and multivariate (generalized estimating equation) tests.
Results
The overall FACT-BMT (p=0.074) and OHIP-14 (p=0.749) scores were not associated with the use of laser therapy. Both instruments showed a deterioration in QoL for the whole sample on D+7. The laser group presented less severe OM than the control group (p<0.001).
Conclusions
LLLT did not influence the oral and general health-related QoL of patients undergoing HSCT, although it was clinically effective in reducing the severity of chemotherapy-induced OM.
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