Caffeine Intake, Coffee Consumption, and Risk of Cutaneous Malignant Melanoma
Wu S, Han J, Song F, Cho E, Gao X, Hunter DJ, Qureshi AA
Epidemiology (Cambridge, Mass.) · 35 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (P01 CA087969); National Cancer Institute (UM1 CA186107); National Cancer Institute (UM1-CA-167552); National Cancer Institute (UM1 CA176726); National Cancer Institute (R01CA137365); National Center for Advancing Translational Sciences (UL1TR-001108); National Cancer Institute ([P01 CA87969)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2015-07-14 · Epidemiology · vol. 26 · número 6 · págs. 898–908
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 45 citas · más que el 96% de estudios similares · 5.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Coffee research and impacts · Skin Protection and Aging · Tea Polyphenols and Effects
- Palabras clave
- Medicine, Caffeine, Melanoma, Hazard ratio, Confidence interval, Proportional hazards model, Lower risk, Cohort study, Cohort, Body mass index, Internal medicine
- MeSH
- humans, melanoma, skin neoplasms, caffeine, diet, proportional hazards models, cohort studies, follow-up studies, prospective studies, coffee, adult, aged, middle aged, united states, female, male
7 autores
- Shaowei Wu🇺🇸 · autor de correspondenciaIndiana University Health; Brigham and Women's Hospital; Harvard University; Indiana University Hospital; Indiana University – Purdue University Indianapolis
- Jiali Han🇺🇸Brown University
- Fengju Song🇺🇸Richard M. Fairbanks Foundation; Indiana University – Purdue University Indianapolis
- Eunyoung Cho🇺🇸Indiana University Health; Indiana Cancer Consortium; Indiana University – Purdue University Indianapolis
- Xiang Gao🇺🇸Indiana University – Purdue University Indianapolis
- David John Hunter🇺🇸Brigham and Women's Hospital
- Abrar A. Qureshi🇨🇳 · autor de correspondenciaTianjin Medical University Cancer Institute and Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Caffeine has been shown to prevent ultraviolet radiation-induced carcinogenesis and to inhibit growth of melanoma cells in experimental studies. We evaluated the association among caffeine intake, coffee consumption, and melanoma risk among three large cohort studies.
Methods
The analysis used data from 89,220 women in the Nurses' Health Study II (1991-2009), 74,666 women in the Nurses' Health Study (1980-2008), and 39,424 men in the Health Professionals Follow-up Study (1986-2008). We used Cox proportional hazards models to estimate the hazard ratios (HR) with 95% confidence intervals (CIs) of melanoma associated with dietary intakes.
Results
We documented 2,254 melanoma cases over 4 million person-years of follow-up. After adjustment for other risk factors, higher total caffeine intake was associated with a lower risk of melanoma (≥393 mg/day vs. <60 mg/day: HR = 0.78, 95% CI = 0.64, 0.96; Ptrend = 0.048). The association was more apparent in women (≥393 mg/day vs. <60 mg/day: HR = 0.70, 95% CI = 0.58, 0.85; Ptrend = 0.001) than in men (HR = 0.94, 95% CI = 0.75, 1.2; Ptrend = 0.81), and more apparent for melanomas occurring on body sites with higher continuous sun exposure (head, neck, and extremities; ≥393 mg/day vs. <60 mg/day: HR = 0.71, 95% CI = 0.59, 0.86; Ptrend = 0.001) than for melanomas occurring on body sites with lower continuous sun exposure (trunk including shoulder, back, hip, abdomen, and chest; HR = 0.90, 95% CI = 0.70, 1.2; Ptrend = 0.60). This pattern of association was similar to that for caffeinated coffee consumption, whereas no association was found for decaffeinated coffee consumption and melanoma risk.
Conclusions
Increasing caffeine intake and caffeinated coffee consumption is associated with decreased risk of cutaneous malignant melanomas.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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