Acute Dietary Nitrate Intake Improves Muscle Contractile Function in Patients With Heart Failure: A Double-Blind, Placebo-Controlled, Randomized Trial
Coggan AR, Leibowitz JL, Spearie CA, Kadkhodayan A, Thomas DP, Ramamurthy S, Mahmood K, Park S, Waller S, Farmer M, Peterson LR
Circulation. Heart failure · 109 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (UL1-TR-000448)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2015-07-16 · Circ Heart Fail · vol. 8 · número 5 · págs. 914–920
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 138 citas · más que el 100% de estudios similares · 37.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Nitric Oxide and Endothelin Effects
- Palabras clave
- Medicine, Heart failure, Crossover study, Ingestion, Internal medicine, Placebo, Cardiology, Dietary Nitrate, Nitric oxide, Blood pressure, Bioavailability, Endocrinology, Nitrate, Nitrite, Pharmacology
- MeSH
- muscle, skeletal, humans, nitrates, exercise, pilot projects, cross-over studies, double-blind method, oxygen consumption, muscle contraction, dose-response relationship, drug, quality of life, dietary supplements, middle aged, female, male, heart failure
11 autores
- Andrew R. Coggan
- Joshua L. Leibowitz
- Catherine Anderson Spearie
- Ana Kadkhodayan
- Deepak P. Thomas
- Sujata Ramamurthy
- Kiran Mahmood
- Soohyung Park
- Suzanne Waller
- Marsha S. Farmer
- Linda R. Peterson
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Skeletal muscle strength, velocity, and power are markedly reduced in patients with heart failure, which contributes to their impaired exercise capacity and lower quality of life. This muscle dysfunction may be partially because of decreased nitric oxide (NO) bioavailability. We therefore sought to determine whether ingestion of inorganic nitrate (NO3 (-)) would increase NO production and improve muscle function in patients with heart failure because of systolic dysfunction.
Methods and results
Using a double-blind, placebo-controlled, randomized crossover design, we determined the effects of dietary NO3 (-) in 9 patients with heart failure. After fasting overnight, subjects drank beetroot juice containing or devoid of 11.2 mmol of NO3 (-). Two hours later, muscle function was assessed using isokinetic dynamometry. Dietary NO3 (-) increased (P<0.05-0.001) breath NO by 35% to 50%. This was accompanied by 9% (P=0.07) and 11% (P<0.05) increases in peak knee extensor power at the 2 highest movement velocities tested (ie, 4.71 and 6.28 rad/s). Maximal power (calculated by fitting peak power data with a parabola) was therefore greater (ie, 4.74±0.41 versus 4.20±0.33 W/kg; P<0.05) after dietary NO3 (-) intake. Calculated maximal velocity of knee extension was also higher after NO3 (-) ingestion (ie, 12.48±0.95 versus 11.11±0.53 rad/s; P<0.05). Blood pressure was unchanged, and no adverse clinical events occurred.
Conclusions
In this pilot study, acute dietary NO3 (-) intake was well tolerated and enhanced NO bioavailability and muscle power in patients with systolic heart failure. Larger-scale studies should be conducted to determine whether the latter translates into an improved quality of life in this population.
Clinical trial registration
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01682356.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.