Financiado en parte por Eli Lilly and Company, Sanofi, Insulet Corporation, Nipro, Roche Diabetes Care, Abbott Diabetes Care
Caffeine Consumption Contributes to Skin Intrinsic Fluorescence in Type 1 Diabetes
Eny KM, Orchard TJ, Miller RG, Maynard J, Grant DM, Costacou T, Cleary PA, Braffett BH, Paterson AD, DCCT/EDIC Research Group
Diabetes technology & therapeutics · 15 citas
Etiquetas de revisión
Vínculos de autores con la industriaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Eli Lilly and Company
- Empresa
- Sanofi
- Organización sin fines de lucro
- Heart and Stroke Foundation of Canada
- Gobierno
- Genome Canada
- Gobierno
- Ontario Genomics
- Empresa
- Insulet Corporation
- Empresa
- Nipro
- Gobierno
- Ontario Genomics Institute
- Empresa
- Roche Diabetes Care
- Gobierno
- National Institutes of Health
- Empresa
- Abbott Diabetes Care
- Gobierno
- National Eye Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (U01-DK-094176); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK077510); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020595); National Institute of Diabetes and Digestive and Kidney Diseases (P60DK20595); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK094176 and U01 DK094157); National Institute of Diabetes and Digestive and Kidney Diseases (U01-DK094157); National Institute of Diabetes and Digestive and Kidney Diseases (R37 DK034818); National Institute of Diabetes and Digestive and Kidney Diseases (DK-34818); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK077489); National Institute of Diabetes and Digestive and Kidney Diseases (N01‐DK‐6‐2204); National Institutes of Health (U01-DK- 094157); National Institutes of Health (P60 DK20595); National Institutes of Health (U01-DK-094176); National Institutes of Health (DK094157); National Institutes of Health (DK094176)
Según 14 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-07-20 · Diabetes Technol Ther · vol. 17 · número 10 · págs. 726–734
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 50 citas · más que el 86% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Coffee research and impacts · Advanced Glycation End Products research · Circadian rhythm and melatonin
- Palabras clave
- Medicine, Diabetes mellitus, Type 2 diabetes, Caffeine, Consumption (sociology), Type 1 diabetes, Fluorescence, Endocrinology, Optics
- MeSH
- skin, humans, diabetes mellitus, type 1, caffeine, arylamine n-acetyltransferase, genotype, fluorescence, coffee, adolescent, adult, female, male, young adult, glycation end products, advanced
9 autores
- Karen M. Eny🇬🇧🇨🇦Great Ormond Street Hospital; Hospital for Sick Children; SickKids Foundation; University College London
- Trevor John Orchard🇺🇸University of Pittsburgh
- Rachel G. Miller🇺🇸University of Pittsburgh
- John Maynard🇺🇸nLIGHT (United States)
- Denis M. Grant🇨🇦University of Toronto
- Tina Costacou🇺🇸University of Pittsburgh
- Patricia A. Cleary🇺🇸George Washington University
- Barbara H. Braffett🇺🇸George Washington University
- Andrew D. Paterson🇨🇦🇬🇧 · autor de correspondenciaUniversity of Toronto; Great Ormond Street Hospital; Hospital for Sick Children; Public Health Ontario; SickKids Foundation; University College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A variant (rs1495741) in the gene for the N-acetyltransferase 2 (NAT2) protein is associated with skin intrinsic fluorescence (SIF), a noninvasive measure of advanced glycation end products and other fluorophores in the skin. Because NAT2 is involved in caffeine metabolism, we aimed to determine whether caffeine consumption is associated with SIF and whether rs1495741 is associated with SIF independently of caffeine.
Materials and methods
SIF was measured in 1,181 participants with type 1 diabetes from the Epidemiology of Diabetes Interventions and Complications study. Two measures of SIF were used: SIF1, using a 375-nm excitation light-emitting diode (LED), and SIF14 (456-nm LED). Food frequency questionnaires were used to estimate mean caffeine intake. To establish replication, we examined a second type 1 diabetes cohort.
Results
Higher caffeine intake was significantly associated with higher SIF1(LED 375 nm[0.6, 0.2]) (P=2×10(-32)) and SIF14L(ED 456 nm[0.4, 0.8]) (P=7×10(-31)) and accounted for 4% of the variance in each after adjusting for covariates. When analyzed together, caffeine intake and rs1495741 both remained highly significantly associated with SIF1(LED 375 nm[0.6, 0.2]) and SIF14(LED 456 nm[0.4, 0.8]). Mean caffeinated coffee intake was also positively associated with SIF1(LED 375 nm[0.6, 0.2]) (P=9×10(-12)) and SIF14(LED 456 nm[0.4, 0.8]) (P=4×10(-12)), but no association was observed for decaffeinated coffee intake. Finally, caffeine was also positively associated with SIF1(LED 375 nm[0.6, 0.2]) and SIF14(LED 456 nm[0.4, 0.8]) (P<0.0001) in the replication cohort.
Conclusions
Caffeine contributes to SIF. The effect of rs1495741 on SIF appears to be partially independent of caffeine consumption. Because SIF and coffee intake are each associated with cardiovascular disease, our findings suggest that accounting for coffee and/or caffeine intake may improve risk prediction models for SIF and cardiovascular disease in individuals with diabetes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.