Maternal Caffeine Consumption during Pregnancy and Risk of Low Birth Weight: A Dose-Response Meta-Analysis of Observational Studies
Rhee J, Kim R, Kim Y, Tam M, Lai Y, Keum N, Oldenburg CE
PloS one · 64 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Harvard T.H. Chan School of Public Health
- Gobierno
- National Institute of Mental Health
- Gobierno
- National Institute on Drug Abuse
- Gobierno
- National Institute of Allergy and Infectious Diseases
- Gobierno
- NIMH NIH HHS
- Gobierno
- NIDA NIH HHS
- Gobierno
- NIAID NIH HHS
- Subvenciones
- National Institute on Drug Abuse (T32-DA013911); National Institute of Allergy and Infectious Diseases (T32-AI-007535); National Institute of Mental Health (R25 MH 083620)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-07-20 · PLoS One · vol. 10 · número 7 · pág. e0132334
- Editorial
- Public Library of Science
- Citado
- 114 citas · más que el 85% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Gestational Diabetes Research and Management · Obesity, Physical Activity, Diet · Birth, Development, and Health
- Palabras clave
- Caffeine, Medicine, Pregnancy, Publication bias, Meta-analysis, Funnel plot, Odds ratio, Low birth weight, Cohort study, Obstetrics, Relative risk, Birth weight, Observational study, Confidence interval, Internal medicine, Biology
- MeSH
- humans, birth weight, caffeine, pregnancy, coffee, infant, newborn, infant, low birth weight, female
7 autores
- Jongeun Rhee🇺🇸 · autor de correspondenciaHarvard University
- Rockli Kim🇺🇸Harvard University
- Yongjoo Kim🇺🇸Harvard University
- Melanie Tam🇺🇸Harvard Global Health Institute
- Yizhen Lai🇺🇸Harvard University
- NaNa Keum🇺🇸Harvard University
- Catherine E. Oldenburg🇺🇸Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Epidemiologic studies have shown inconsistent conclusions about the effect of caffeine intake during pregnancy on the risk of low birth weight (LBW). We performed a meta-analysis and linear-dose response analysis examining the association between caffeine consumption during pregnancy and risk of LBW. PubMed and EMBASE were searched for relevant articles published up to March 2014. Eight cohort and four case-control studies met all inclusion criteria. Using a random-effects model of the twelve studies, the pooled odds ratio (OR) for the risk of LBW comparing the highest versus lowest level of caffeine intake during pregnancy was 1.38 (95% CI: 1.10, 1.73). Linear dose-response analysis showed that every additional 100 mg of caffeine intake (1 cup of coffee or 2 cups of tea) per day during pregnancy was associated with a 3.0% increase in OR for LBW. There was a moderate level of overall heterogeneity with an I-squared value of 55% (95% CI: 13, 76%), and no evidence of publication bias based on Egger's test (P = 0.20) and the funnel plot. Thus, high caffeine intake during pregnancy is associated with a significant increase in the risk of LBW, and this risk appears to increase linearly as caffeine intake increases.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.