The role of outcome expectancies for a training program consisting of meditation, breathing exercises, and cold exposure on the response to endotoxin administration: a proof-of-principle study
van Middendorp H, Kox M, Pickkers P, Evers AW
Clinical rheumatology · 16 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Dutch Arthritis Association
Según 1 financiador declarado.
Publicación
- Publicado
- 2015-07-20 · Clin Rheumatol · vol. 35 · número 4 · págs. 1081–1085
- Editorial
- Springer Science+Business Media
- Citado
- 24 citas · más que el 89% de estudios similares · 2.7× el promedio de su campo
- Referencias
- 27 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Mindfulness and Compassion Interventions · Stress Responses and Cortisol · Pain Management and Placebo Effect
- Palabras clave
- outcome expectations, optimism, neuroticism, meditation, breathing exercises, cold exposure, endotoxemia, immune response, IL-10, epinephrine, autonomic responses, psychological stress response, training program
- MeSH
- autonomic nervous system, immune system, humans, endotoxemia, inflammation, tumor necrosis factor-alpha, interleukin-8, interleukin-6, interleukin-10, endotoxins, treatment outcome, meditation, respiration, research design, adult, male, cold temperature, young adult, anticipation, psychological, healthy volunteers, optimism
4 autores
- Henriët van Middendorp🇳🇱Leiden University
- Matthijs Kox🇳🇱Radboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Peter Pickkers🇳🇱Radboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Andrea W.M. Evers🇳🇱 · autor de correspondenciaLeiden University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Expectancies play a major role for the treatment outcome of a broad variety of immune-mediated conditions and may strengthen or mimic the effects of regular long-term therapies. This study adds to a recently published study of Kox et al. (PNAS 111:7379-7384, 2014) on the ability to voluntarily influence the physiological stress response in healthy men after a training program consisting of meditation, breathing techniques, and exposure to cold, which found highly promising results on the clinical, autonomic, and immune response to experimentally induced inflammation (using the experimental human endotoxemia model). Within this project, a number of variables were included to assess the role of generalized (optimism, neuroticism) and specific outcome expectancies (related to the effects of the training on health) on the response to endotoxin administration after training. Indications were found that especially the generalized outcome expectancy optimism is a potential determinant of the autonomic (epinephrine: rho = 0.76, p < .01) and immune response (interleukin-10: rho = 0.60, p < .05) to induced inflammation after training, whereas more specific expectations with regard to the effects of the training could be especially relevant for the clinical symptom report (flu-like symptoms: rho = -0.71, p < .01). This proof-of-principle study provides first indications for potential innovative treatments to change immune-modulating responses by means of psychological mechanisms. If replicated, these findings may be used for predicting training responses and potentiate their effects by means of optimism-inducing interventions in patients with immune-mediated rheumatic conditions.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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