Nonlinear Reduction in Risk for Type 2 Diabetes by Magnesium Intake: An Updated Meta-Analysis of Prospective Cohort Studies
Xu T, Chen GC, Zhai L, Ke KF
Biomedical and environmental sciences : BES · 18 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-07-01 · Biomed Environ Sci · vol. 28 · número 7 · págs. 527–34
- Editorial
- National Institutes of Health
- Citado
- 22 citas · más que el 59% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Therapeutic Uses of Natural Elements · Plant Micronutrient Interactions and Effects
- Palabras clave
- Medicine, Meta-analysis, Type 2 diabetes, Diabetes mellitus, Prospective cohort study, Cohort study, Internal medicine, Relative risk, Subgroup analysis, Magnesium, Endocrinology, Confidence interval, Chemistry
- MeSH
- humans, diabetes mellitus, type 2, magnesium, risk, least-squares analysis, prospective studies, dose-response relationship, drug, nonlinear dynamics
4 autores
- Xu Tian🇨🇳Nantong University; Affiliated Hospital of Nantong University
- Guo Chong Chen🇨🇳Nantong University; Affiliated Hospital of Nantong University
- Lin Zhai🇨🇳Nantong University; Affiliated Hospital of Nantong University
- Kai Fu Ke🇨🇳Nantong University; Affiliated Hospital of Nantong University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Observational studies between magnesium int- ake and risk of type 2 diabetes yielded inconsistent results. We conducted a system literature search of PubMed database through March 2015 for prospective cohort studies of magnesium intake and type 2 diabetes risk. Study-specific results were pooled in a random-effects model. Subgroup and sensitivity analysis were performed to assess the potential sources of heterogeneity and the robustness of the pooled estimation. Generalized least squares trend estimation was used to investigate the dose-response relationship. A total of 15 papers with 19 analyses were identified with 539,735 participants and 25,252 incident diabetes cases. Magnesium intake was associated with a significant lower risk of type 2 diabetes (RR: 0.77; 95% CI: 0.71-0.82) for the highest compared with lowest category. This association was not significantly modified by the pre-specified study characteristics. In the dose-response analysis, a magnesium intake increment of 100 mg/day was associated with a 16% reduction in type 2 diabetes risk (RR: 0.84; 95% CI: 0.80-0.88). A nonlinear relationship existed between magnesium intake and type 2 diabetes (P-nonlinearity=0.003). This meta-analysis further verified a protective effect of magnesium intake on type 2 diabetes in a nonlinear dose-response manner.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.