Effect of Spinach, a High Dietary Nitrate Source, on Arterial Stiffness and Related Hemodynamic Measures: A Randomized, Controlled Trial in Healthy Adults
Jovanovski E, Bosco L, Khan K, Au-Yeung F, Ho H, Zurbau A, Jenkins AL, Vuksan V
Clinical nutrition research · 36 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- St. Michael's Hospital
- Universidad u hospital
- Li Ka Shing Knowledge Institute
Según 2 financiadores declarados.
Publicación
- Publicado
- 2015-01-01 · Clin Nutr Res · vol. 4 · número 3 · pág. 160
- Citado
- 70 citas · más que el 93% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects · Blood Pressure and Hypertension Studies
- Palabras clave
- Arterial stiffness, Medicine, Nitrate, Crossover study, Blood pressure, Spinach, Pulse wave velocity, Nitric oxide, Pulse pressure, Placebo, Internal medicine, Hemodynamics, Animal science, Cardiology, Biochemistry, Chemistry, Biology
8 autores
- Elena Jovanovski🇨🇦St. Michael's Hospital; University of Toronto
- Laura Bosco🇨🇦St. Michael's Hospital; University of Toronto
- Kashif Khan🇨🇦St. Michael's Hospital
- Fei Au‐Yeung🇨🇦St. Michael's Hospital
- Hoang Ho🇨🇦St. Michael's Hospital; University of Toronto
- Andreea Zurbau🇨🇦St. Michael's Hospital
- Alexandra L. Jenkins🇨🇦St. Michael's Hospital
- Vladimir V.V. Vuksan🇨🇦🇬🇧 · autor de correspondenciaSt. Michael's Hospital; University of Toronto; St Michael's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Diets rich in fruits and vegetables reduce risk of adverse cardiovascular events. However, the constituents responsible for this effect have not been well established. Lately, the attention has been brought to vegetables with high nitrate content with evidence that this might represent a source of vasoprotective nitric oxide. We hypothesized that short-term consumption of spinach, a vegetable having high dietary nitrate content, can affect the arterial waveform indicative of arterial stiffness, as well as central and peripheral blood pressure (BP). Using a placebo-controlled, crossover design, 27 healthy participants were randomly assigned to receive either a high-nitrate (spinach; 845 mg nitrate/day) or low-nitrate soup (asparagus; 0.6 mg nitrate/day) for 7 days with a 1-week washout period. On days 1 and 7, profiles of augmentation index, central, and brachial BP were obtained over 180 min post-consumption in 4 fasted visits. A postprandial reduction in augmentation index was observed at 180 min on high-nitrate compared to low-nitrate intervention (-6.54 ± 9.7% vs. -0.82 ± 8.0%, p = 0.01) on Day 1, and from baseline on Day 7 (-6.93 ± 8.7%, p < 0.001; high vs. low: -2.28 ± 12.5%, p = 0.35), suggesting that the nitrate intervention is not associated with the development of tolerance for at least 7 days of continued supplementation. High vs. low-nitrate intervention also reduced central systolic (-3.39 ± 5.6 mmHg, p = 0.004) and diastolic BP (-2.60 ± 5.8 mmHg, p = 0.028) and brachial systolic BP (-3.48 ± 7.4 mmHg, p = 0.022) at 180 min following 7-day supplementation only. These findings suggest that dietary nitrate from spinach may contribute to beneficial hemodynamic effects of vegetable-rich diets and highlights the potential of developing a targeted dietary approach in the management of elevated BP.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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