Financiado en parte por Sanofi, Meat and Livestock Australia
The effects of a protein enriched diet with lean red meat combined with a multi-modal exercise program on muscle and cognitive health and function in older adults: study protocol for a randomised controlled trial
Daly RM, Gianoudis J, Prosser M, Kidgell D, Ellis KA, O'Connell S, Nowson CA
Trials · 36 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Sanofi
- Grupo de la industria
- Meat and Livestock Australia
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-08-07 · Trials · vol. 16 · número 1 · pág. 339
- Editorial
- Springer Science+Business Media
- Citado
- 50 citas · más que el 88% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 82 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Nutritional Studies and Diet
- Palabras clave
- Medicine, Lean body mass, Red meat, Wasting, Cognition, Physical therapy, Cognitive decline, Gerontology, Dementia, Internal medicine, Body weight, Pathology
- MeSH
- muscle, skeletal, humans, dietary proteins, treatment outcome, clinical protocols, combined modality therapy, geriatric assessment, mental health, cognition, cognition disorders, age factors, aging, research design, time factors, quality of life, aged, victoria, female, male, muscle strength, resistance training, sarcopenia, biomarkers, surveys and questionnaires, red meat
7 autores
- Robin M. Daly🇦🇺 · autor de correspondenciaDeakin University
- Jenny Gianoudis🇦🇺Deakin University
- Melissa Prosser🇦🇺Deakin University
- Dawson J. Kidgell🇦🇺Deakin University; La Trobe University
- Kathryn A. Ellis🇦🇺The University of Melbourne
- Stella L. O’Connell🇦🇺Deakin University
- Caryl Anne Nowson🇦🇺Deakin University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Age-related muscle wasting has been strongly implicated with falls and fractures in the elderly, but it has also been associated with cognitive decline and dementia. Progressive resistance training (PRT) and adequate dietary protein are recognised as important contributors to the maintenance of muscle health and function in older adults. However, both factors also have the potential to improve brain function and prevent cognitive decline via several pathways, including the regulation of various growth and neurotrophic factors [insulin-like growth factor-1 (IGF-1)]; brain-derived growth factor (BDNF)] and/or the modulation of systemic inflammation. The primary aim of this study is to investigate whether a modest increase in dietary protein achieved through the consumption of lean red meat three days per week, when combined with PRT, can enhance muscle mass, size and strength and cognitive function in community-dwelling older people.
Methods/design
The study design is a 48-week randomised controlled trial consisting of a 24-week intervention with a 24-week follow-up. Men and women (n=152) aged 65 years and over residing in the community will be randomly allocated to: 1) PRT and provided with 220 g (raw weight) of lean red meat to be cooked and divided into two 80 g servings on each of the three days that they complete their exercise session, or 2) control PRT in which participants will be provided with and advised to consume ≥1 serving (~1/2 cup) of rice and/or pasta or 1 medium potato on each of the three training days. The primary outcome measures will be muscle mass, size and strength and cognitive function. Secondary outcomes will include changes in: muscle function, neural health (corticospinal excitability and inhibition and voluntary activation), serum IGF-1 and BDNF, adipokines and inflammatory markers, fat mass and inter-/intra-muscular fat, blood pressure, lipids and health-related quality of life. All outcome measures will be assessed at baseline and 24 weeks, with the exception of cognitive function and the various neurobiological and inflammatory markers which will also be assessed at week 12.
Discussion
The findings from this study will provide important new information on whether a modest increase in dietary protein achieved through the ingestion of lean red meat can enhance the effects of PRT on muscle mass, size and strength as well as cognitive function in community-dwelling older adults. If successful, the findings will form the basis for more precise exercise and nutrition guidelines for the management and prevention of age-related changes in muscle and neural health and cognitive function in the elderly.
Trial registration
Australian New Zealand Clinical Trials Registry: ACTRN12613001153707 . Date registered 16(th) October, 2013.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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