Effect of Extra Virgin Olive Oil on Biomarkers of Inflammation in HIV-Infected Patients: A Randomized, Crossover, Controlled Clinical Trial
Kozić Dokmanović S, Kolovrat K, Laškaj R, Jukić V, Vrkić N, Begovac J
Medical science monitor : international medical journal of experimental and clinical research · 13 citas
Etiquetas de revisión
Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-01-01 · Med Sci Monit · vol. 21 · págs. 2406–2413
- Editorial
- International Scientific Information Inc.
- Citado
- 16 citas · más que el 76% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- HIV-related health complications and treatments · Edible Oils Quality and Analysis · Fatty Acid Research and Health
- Palabras clave
- extra virgin olive oil, HIV infection, inflammatory markers, high-sensitivity C-reactive protein, antiretroviral therapy, premature atherosclerosis, oxidative stress, lipid profile, lopinavir/ritonavir, dietary intervention
- MeSH
- humans, hiv infections, ritonavir, c-reactive protein, inflammation mediators, drug combinations, hiv protease inhibitors, antiretroviral therapy, highly active, cross-over studies, single-blind method, food handling, adolescent, adult, aged, middle aged, male, atherosclerosis, young adult, lopinavir, biomarkers, olive oil
1 autor
- Josip Begovać🇭🇷 · autor de correspondenciaUniversity of Zagreb; University Hospital for Infectious Diseases "Dr Fran Mihaljevic"
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Premature atherosclerosis in HIV-infected patients is associated with chronic infection by itself and adverse effects of antiretroviral treatment (ART). Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties. The objective of this study was to determine whether the consumption of EVOO improves inflammation and atherosclerosis biomarkers in HIV-infected patients receiving ART.
Material and methods
This randomized, crossover, controlled trial included 39 HIV-positive male participants who consumed 50 mL of EVOO or refined olive oil (ROO) daily. Four participants dropped out of the study. Leukocyte count, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), interleukin-6, fibrinogen, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, malondialdehyde, glutathione-peroxidase, superoxide dismutase, oxidized LDL and von Willebrand factor were determined before the first and after each of the 2 intervention periods. Intervention and washout periods lasted for 20 and 14 days, respectively.
Results
In participants with >90% compliance (N=30), hsCRP concentrations were lower after EVOO intervention (geometric mean [GM], 1.70 mg/L; 95% confidence interval [CI], 1.15-2.52) compared to ROO administration (GM, 2.92 mg/L; 95% CI, 1.95-4.37) (p=0.035). In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration. In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration.
Conclusions
Our exploratory study suggests that EVOO consumption could lower hsCRP in patients on ART.
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