Topical application of a linoleic acid-ceramide containing moisturizer exhibit therapeutic and preventive benefits for psoriasis vulgaris: a randomized controlled trial
Liu M, Li X, Chen XY, Xue F, Zheng J
Dermatologic therapy · 40 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Science and Technology Commission of Shanghai Municipality
- Universidad u hospital
- School of Medicine, Shanghai Jiao Tong University
- Gobierno
- H2020 European Research Council
- Subvenciones
- Science and Technology Commission of Shanghai Municipality (11JC1407500)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2015-08-19 · Dermatol Ther · vol. 28 · número 6 · págs. 373–382
- Editorial
- Wiley
- Citado
- 61 citas · más que el 73% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 80 trabajos
- Acceso
- De pago
- Áreas de investigación
- Psoriasis: Treatment and Pathogenesis · Dermatology and Skin Diseases · Advancements in Transdermal Drug Delivery
- Palabras clave
- plaque psoriasis, linoleic acid, ceramide, emollients, topical treatment, adjunctive therapy, epidermal permeability barrier, transepidermal water loss, capacitance, PASI, mometasone furoate, relapse prevention
- MeSH
- skin, humans, psoriasis, ceramides, linoleic acid, dermatologic agents, glucocorticoids, treatment outcome, administration, cutaneous, severity of illness index, water loss, insensible, time factors, adolescent, adult, aged, aged, 80 and over, middle aged, child, china, female, male, young adult, skin cream, mometasone furoate
5 autores
- Min Liu🇨🇳Shanghai Jiao Tong University; Ruijin Hospital
- Xia Li🇨🇳 · autor de correspondenciaShanghai Jiao Tong University; Ruijin Hospital
- Xiaoying Chen🇨🇳Shanghai Jiao Tong University; Ruijin Hospital
- Feng Xue🇨🇳Shanghai Jiao Tong University; Ruijin Hospital
- Jie Zheng🇨🇳Shanghai Jiao Tong University; Ruijin Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Psoriasis is a chronic skin inflammatory disorder with frequent relapse. Ceramides and their key enzymes are deficient in the lesions, resulting in impaired epidermal permeability barrier, which correlates with disease severity. We evaluated the efficacy of linoleic acid-ceramide moisturizer (LA-Cer) as an adjunctive and preventive therapy for psoriasis vulgaris. 106 patients were randomized into two groups. The control group (C1 ) received Mometasone Furoate 0.1% Cream (MF) while the treatment group (T1 ) was given 0.1% MF in combination with LA-Cer moisturizer. Psoriasis Area and Severity Index (PASI), pruritus, capacitance (CAP), and transepidermal water loss (TEWL) of normal skin and lesion were evaluated at Week 0, 2, 4, 8. Subsequently, T1 patients were randomized for another 1 year. LA-Cer-group (T2 ) maintained the use of moisturizer while control group (C2 ) discontinued. CAPs, TEWLs, PASI were assessed after 1 year. Primary endpoints (PASI-50 at Week 8) revealed superiority of LA-Cer-MF versus MF, less relapse, and rebound in LA-Cer-group than control (C2 ) at Year 1. There were time-by-therapy interaction effect on CAPs, lesional TEWL, and PASI. LA-Cer-MF induced higher CAP, an earlier reduction of lesional TEWL and PASI than control (C1 ). CAPs, lesional TEWL, and PASI remained stable in LA-Cer-group. CAPs, lesional TEWL, and PASI were comparable to the baseline levels in control group (C2 ). Topical LA-Cer moisturizer can alleviate psoriasis, and could be a valuable approach for the treatment and prevention of psoriasis.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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