Egg intake and cancers of the breast, ovary and prostate: a dose-response meta-analysis of prospective observational studies
Keum N, Lee DH, Marchand N, Oh H, Liu H, Aune D, Greenwood DC, Giovannucci EL
The British journal of nutrition · 32 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-08-21 · Br J Nutr · vol. 114 · número 7 · págs. 1099–1107
- Editorial
- Cambridge University Press
- Citado
- 44 citas · más que el 58% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 66 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Cancer, Lipids, and Metabolism · Cancer Risks and Factors
- Palabras clave
- Medicine, Meta-analysis, Relative risk, Breast cancer, Prospective cohort study, Prostate cancer, Internal medicine, Prostate, Oncology, Gynecology, Publication bias, Etiology, Cancer, Physiology, Confidence interval
- MeSH
- humans, breast neoplasms, ovarian neoplasms, prostatic neoplasms, choline, cholesterol, diet, risk factors, dose-response relationship, drug, eggs, databases, factual, female, male, observational studies as topic
8 autores
- NaNa Keum🇺🇸 · autor de correspondenciaHarvard University
- Dong Hoon Lee🇺🇸Harvard University
- Nathalie E. Marchand🇺🇸Harvard University
- Hannah Oh🇺🇸Harvard University
- Huijun Liu🇨🇳Zhejiang A & F University; Zhejiang University
- Dagfinn Aune🇳🇴🇬🇧Norwegian University of Science and Technology; Imperial College London
- Darren Charles Greenwood🇬🇧University of Leeds
- Edward L. Giovannucci🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Evidence suggests that egg intake may be implicated in the aetiology of sex hormone-related cancers. However, dose-response relationships between egg intake and such cancers are unclear. Thus, we conducted a dose-response meta-analysis to summarise the dose-response relationships between egg consumption and the risk of breast, prostate and gynaecological cancers. A literature search was performed using PubMed and Embase up to April 2015 to identify relevant prospective observational studies. Summary relative risk (RR) and 95% CI were estimated using a random-effects model. For breast cancer, the linear dose-response meta-analysis found a non-significantly increased risk (RR for an increase of 5 eggs consumed/week: 1·05, 95% CI 0·99, 1·11, n 16,023 cases). Evidence for non-linearity was not statistically significant (P non-linearity= 0·50, n 15,415 cases) but consuming ≥ 5 eggs/week was significantly associated with an increased risk of breast cancer compared with no egg consumption, with the summary RR being 1·04 (95% CI 1·01, 1·07) for consuming 5 eggs/week and 1·09 (95% CI 1·03, 1·15) for consuming about 9 eggs/week. For other cancers investigated, the summary RR for an increase of 5 eggs consumed/week was 1·09 (95% CI 0·96, 1·24, n 2636 cases) for ovarian cancer; 1·47 (95% CI 1·01, 2·14, n 609 cases) for fatal prostate cancer, with evidence of small-study effects (P Egger= 0·04). No evidence was found for an association with the risk of total prostate cancer. While our conclusion was tempered by the potential for publication bias and confounding, high egg intake may be associated with a modestly elevated risk of breast cancer, and a positive association between egg intake and ovarian and fatal prostate cancers cannot be ruled out.
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