Financiado en parte por Pfizer, Pfizer Foundation
Nut consumption is inversely associated with both cancer and total mortality in a Mediterranean population: prospective results from the Moli-sani study
Bonaccio M, Di Castelnuovo A, De Curtis A, Costanzo S, Bracone F, Persichillo M, Donati MB, de Gaetano G, Iacoviello L, Moli-sani Project investigators
The British journal of nutrition · 42 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoFinanciado por la industriaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Pfizer
- Gobierno
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Organización sin fines de lucro
- Fondazione Umberto Veronesi
- Gobierno
- Regione Molise
- Empresa
- Pfizer Foundation
Según 5 financiadores declarados.
Publicación
- Publicado
- 2015-08-27 · Br J Nutr · vol. 114 · número 5 · págs. 804–811
- Editorial
- Cambridge University Press
- Citado
- 53 citas · más que el 96% de estudios similares · 5.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Nutrition, Health and Food Behavior
- Palabras clave
- Medicine, Hazard ratio, Nut, Prospective cohort study, Mediterranean diet, Proportional hazards model, Cancer, Confounding, Population, Internal medicine, Epidemiology, Demography, Confidence interval, Environmental health
- MeSH
- humans, nuts, neoplasms, cardiovascular diseases, inflammation, c-reactive protein, cause of death, proportional hazards models, risk factors, prospective studies, diet, mediterranean, adult, aged, middle aged, italy, female, male, biomarkers, surveys and questionnaires
9 autores
- Marialaura Bonaccio🇮🇹 · autor de correspondenciaIstituto Neurologico Mediterraneo; Fondazione Umberto Veronesi
- Augusto Filippo Di Castelnuovo🇮🇹Istituto Neurologico Mediterraneo
- Amalia De Curtis🇮🇹Istituto Neurologico Mediterraneo
- Simona Costanzo🇮🇹Istituto Neurologico Mediterraneo
- Francesca Bracone🇮🇹Istituto Neurologico Mediterraneo
- Mariarosaria Persichillo🇮🇹Istituto Neurologico Mediterraneo
- Maria Benedetta Donati🇮🇹Istituto Neurologico Mediterraneo
- Giovanni de Gaetano🇮🇹Istituto Neurologico Mediterraneo
- Licia Iacoviello🇮🇹Istituto Neurologico Mediterraneo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Nut intake has been associated with reduced inflammatory status and lower risk of CVD and mortality. The aim of this study was to examine the relationship between nut consumption and mortality and the role of inflammation. We conducted a population-based prospective investigation on 19 386 subjects enrolled in the Moli-sani study. Food intake was recorded by the Italian version of the European Project Investigation into Cancer and Nutrition FFQ. C-reactive protein, leucocyte and platelet counts and the neutrophil:lymphocyte ratio were used as biomarkers of low-grade inflammation. Hazard ratios (HR) were calculated using multivariable Cox proportional hazard models. During a median follow-up of 4·3 years, 334 all-cause deaths occurred. As compared with subjects who never ate nuts, rare intake (≤2 times/month) was inversely associated with mortality (multivariable HR=0·68; 95 % CI 0·54, 0·87). At intake ≥8 times/month, a greater protection was observed (HR=0·53; 0·32, 0·90). Nut intake (v. no intake) conveyed a higher protection to individuals poorly adhering to the Mediterranean diet (MD). A significant reduction in cancer deaths (HR=0·64; 95 % CI 0·44, 0·94) was also observed, whereas the impact on CVD deaths was limited to an inverse, but not significant, trend. Biomarkers of low-grade inflammation were reduced in nut consumers but did not account for the association with mortality. In conclusion, nut intake was associated with reduced cancer and total mortality. The protection was stronger in individuals with lower adherence to MD, whereas it was similar in high-risk groups (diabetics, obese, smokers or those with the metabolic syndrome), as compared with low-risk subjects. Inflammation did not explain the observed relationship.
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