Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose-response meta-analysis of prospective studies
Chen LW, Wu Y, Neelakantan N, Chong MF, Pan A, van Dam RM
Public health nutrition · 58 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- National University of Singapore
Según 1 financiador declarado.
Publicación
- Publicado
- 2015-09-02 · Public Health Nutr · vol. 19 · número 7 · págs. 1233–1244
- Editorial
- Cambridge University Press
- Citado
- 104 citas · más que el 77% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 80 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Gestational Diabetes Research and Management · Cancer Risks and Factors
- Palabras clave
- Medicine, Pregnancy, Confounding, Caffeine, Relative risk, Meta-analysis, Prospective cohort study, Obstetrics, Publication bias, Confidence interval, Internal medicine
- MeSH
- humans, abortion, spontaneous, caffeine, risk factors, pregnancy, dose-response relationship, drug, coffee, databases, factual, female
6 autores
- Ling‐Wei Chen🇸🇬 · autor de correspondenciaNational University of Singapore; National University Health System
- Yi Ming Wu🇸🇬National University of Singapore; National University Health System
- Nithya Neelakantan🇸🇬National University of Singapore; National University Health System
- Mary Foong‐Fong Chong🇸🇬National University of Singapore; Singapore Institute for Clinical Sciences; National University Health System; Clinical Nutrition Research Centre
- An Pan🇸🇬National University of Singapore; National University Health System
- Rob M. van Dam🇺🇸🇸🇬 · autor de correspondenciaHarvard University; National University of Singapore; National University Health System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To assess the association between maternal caffeine intake and risk of pregnancy loss using a systematic review and meta-analysis.
Design
Categorical and dose-response meta-analysis of prospective studies.
Setting
Relevant articles were identified by searching MEDLINE and SCOPUS databases through 30 January 2015. Two authors independently extracted information from eligible studies. Random-effects models were used to derive the summary relative risks (RR) and corresponding 95% CI for specific categories of caffeine consumption and for a continuous association using generalized least-squares trend estimation.
Subjects
A total of 130 456 participants and 3429 cases in fourteen included studies.
Results
Compared with the reference category with no or very low caffeine intake, the RR (95% CI) of pregnancy loss was 1·02 (0·85, 1·24; I(2)=28·3%) for low intake (50-149 mg/d), 1·16 (0·94, 1·41; I 2=49·6%) for moderate intake (150-349 mg/d), 1·40 (1·16, 1·68; I(2)=18·6%) for high intake (350-699 mg/d) and 1·72 (1·40, 2·13; I(2)=0·0%) for very high intake (≥ 700 mg/d). In the dose-response analysis, each 100 mg/d increment in maternal caffeine intake (~1 cup of coffee) was associated with 7% (95% CI 3%, 12%) higher risk of pregnancy loss. Our results may have been affected by publication bias, but the association remained significant for the subset of larger studies. Furthermore, adjustment for smoking and pregnancy symptoms may have been incomplete, potentially resulting in residual confounding.
Conclusions
Albeit inconclusive, higher maternal caffeine intake was associated with a higher risk of pregnancy loss and adherence to guidelines to avoid high caffeine intake during pregnancy appears prudent.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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