Dietary Omega-3 Fatty Acid Supplementation Reduces Inflammation in Obese Pregnant Women: A Randomized Double-Blind Controlled Clinical Trial
Haghiac M, Yang XH, Presley L, Smith S, Dettelback S, Minium J, Belury MA, Catalano PM, Hauguel-de Mouzon S
PloS one · 116 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- U.S. Public Health Service
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NICHD NIH HHS
- Gobierno
- NCATS NIH HHS
- Gobierno
- PHS HHS
- Subvenciones
- National Center for Advancing Translational Sciences (UL1-TR-000439); U.S. Public Health Service (RHD057236); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD057236); National Institutes of Health (RHD057236)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-09-04 · PLoS One · vol. 10 · número 9 · pág. e0137309
- Editorial
- Public Library of Science
- Citado
- 140 citas · más que el 99% de estudios similares · 11.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Pregnancy and preeclampsia studies
- Palabras clave
- omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, maternal obesity, inflammation, placenta, adipose tissue, TLR4, interleukin-6, interleukin-8, TNF-α, C-reactive protein, n-6/n-3 ratio, trophoblast, palmitate, dietary supplementation
- MeSH
- adipose tissue, trophoblasts, placenta, humans, obesity, inflammation, docosahexaenoic acids, eicosapentaenoic acid, interleukin-8, interleukin-6, diet, double-blind method, signal transduction, gene expression regulation, pregnancy, dietary supplements, adult, female, toll-like receptor 4, primary cell culture
9 autores
- Maricela Haghiac🇺🇸MetroHealth; MetroHealth Medical Center
- Xiao-hua Yang🇺🇸MetroHealth; MetroHealth Medical Center
- Larraine Huston Presley🇺🇸MetroHealth; MetroHealth Medical Center
- Shoi Smith🇺🇸MetroHealth; MetroHealth Medical Center
- Shirley Dettelback🇺🇸MetroHealth; MetroHealth Medical Center
- Judi Minium🇺🇸MetroHealth; MetroHealth Medical Center
- Martha Ann Belury🇺🇸The Ohio State University
- Patrick M. Catalano🇺🇸MetroHealth; MetroHealth Medical Center
- Sylvie Hauguel‐de Mouzon🇺🇸 · autor de correspondenciaMetroHealth; MetroHealth Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Long-chain omega 3 fatty acids, eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) exert potent anti-inflammatory properties in humans. This study characterized the effects of omega-3 ω-3 fatty acids supplements (ω-3 FA) on the inflammatory status in the placenta and adipose tissue of overweight/obese pregnant women.
Study design
A randomized, double-masked controlled trial was conducted in overweight/obese pregnant women that were randomly assigned to receive DHA plus EPA (2 g/day) or the equivalent of a placebo twice a day from week 10-16 to term. Inflammatory pathways were characterized in: 1) adipose tissue and placenta of treated vs. untreated women; and 2) adipose and trophoblast cells cultured with long chain FAs.
Results
The sum of plasma DHA and EPA increased by 5.8 fold and ω-3 FA/ω-6 FA ratio was 1.5 in treated vs. untreated women (p< 0.005). Plasma CRP concentrations were reduced (p<0.001). The adipose tissue and placenta of treated women exhibited a significant decrease in TLR4 adipose and placental expression as well as IL6, IL8, and TNFα In vitro, EPA and DHA suppressed the activation of TLR4, IL6, IL8 induced by palmitate in culture of adipose and trophoblast cells.
Conclusion
Supplementation of overweight/obese pregnant women with dietary ω-3 FAs for >25 weeks reduced inflammation in maternal adipose and the placental tissue. TLR4 appears as a central target of the anti-inflammatory effects at the cellular level.
Trial registration
ClinicalTrials.gov NCT00957476.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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