Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis
Del Pinto R, Pietropaoli D, Chandar AK, Ferri C, Cominelli F
Inflammatory bowel diseases · 197 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 091222); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK055812); National Institute of Diabetes and Digestive and Kidney Diseases (DK 055812); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK067629); National Institute of Diabetes and Digestive and Kidney Diseases (R56 DK055812); National Institute of Diabetes and Digestive and Kidney Diseases (R56DK042191); National Institute of Diabetes and Digestive and Kidney Diseases (DK042191); National Institute of Diabetes and Digestive and Kidney Diseases (P01DK091222); National Institute of Diabetes and Digestive and Kidney Diseases (R37DK042191); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK042191); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK097948)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2015-08-13 · Inflamm Bowel Dis · vol. 21 · número 11 · págs. 2708–2717
- Editorial
- Oxford University Press
- Citado
- 244 citas · más que el 99% de estudios similares · 12.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 92 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Inflammatory Bowel Disease · Vitamin K Research Studies
- Palabras clave
- inflammatory bowel disease, vitamin D deficiency
- MeSH
- humans, inflammatory bowel diseases, vitamin d deficiency, vitamin d, odds ratio, observational studies as topic
5 autores
- Rita Del Pinto🇮🇹🇺🇸University of L'Aquila; San Salvatore Hospital; University Hospitals Cleveland Medical Center; Case Western Reserve University
- Davide Pietropaoli🇮🇹🇺🇸University of L'Aquila; San Salvatore Hospital; Case Western Reserve University
- Apoorva Krishna Chandar🇺🇸University Hospitals of Cleveland; University Hospitals Cleveland Medical Center; Case Western Reserve University
- Claudio Ferri🇮🇹University of L'Aquila; San Salvatore Hospital
- Fabio Cominelli🇺🇸University Hospitals of Cleveland; University Hospitals Cleveland Medical Center; Case Western Reserve University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D plays a role in several immune-mediated diseases, but its association with inflammatory bowel disease (IBD) is unclear. We conducted a systematic review and meta-analysis to assess the association between IBD and vitamin D deficiency.
Methods
We searched electronic databases from inception to December 2014 for observational studies reporting the presence of vitamin D deficiency (defined as serum 25-hydroxycholecalciferol [25(OH)D] level of ≤20 ng/mL) in IBD patients and having a control group without IBD. Odds ratios (ORs) were combined using a random-effects model. Meta-regression was performed using latitude as a moderator. Study quality was assessed using the Newcastle-Ottawa scale.
Results
Out of 816 citations, 14 eligible studies were identified, comprising 1891 participants (938 IBD cases and 953 controls). Meta-analysis showed that patients with IBD had 64% higher odds of vitamin D deficiency when compared with controls (OR = 1.64; 95% confidence interval, 1.30-2.08; I = 7%; P < 0.0001). Patients with ulcerative colitis had more than double the odds of vitamin D deficiency when compared with normal controls (OR = 2.28; 95% confidence interval, 1.18-4.41; I = 41%; P = 0.01). Latitude did not influence the association between IBD and vitamin D deficiency (P = 0.34). Generalizability of our results might be limited as we summarized unadjusted ORs, because of nonavailability of adjusted ORs in individual studies.
Conclusions
IBD is significantly associated with having higher odds of vitamin D deficiency. Well-designed randomized controlled trials and longitudinal studies are needed to further explain the role of vitamin D in IBD pathogenesis and its therapy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.