Pregnancy-induced changes in the pharmacokinetics of caffeine and its metabolites
Yu T, Campbell SC, Stockmann C, Tak C, Schoen K, Clark EA, Varner MW, Spigarelli MG, Sherwin CM
Journal of clinical pharmacology · 46 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Utah
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Organización sin fines de lucro
- Primary Children Hospital Foundation
- Subvenciones
- National Heart, Lung, and Blood Institute (T35HL007744)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2015-09-11 · J Clin Pharmacol · vol. 56 · número 5 · págs. 590–596
- Editorial
- Wiley
- Citado
- 69 citas · más que el 95% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Pregnancy and Medication Impact · Pharmacogenetics and Drug Metabolism · Coffee research and impacts
- Palabras clave
- Paraxanthine, Caffeine, Theobromine, Theophylline, Urine, Pharmacokinetics, Metabolite, Pregnancy, CYP1A2, Medicine, Endocrinology, Internal medicine, Pharmacology, Physiology, Metabolism, Chemistry, Biology
- MeSH
- humans, caffeine, theobromine, theophylline, cytochrome p-450 cyp1a2, pregnancy, pregnancy trimesters, adult, female, young adult
9 autores
- Yu Tian🇺🇸University of Utah
- Sarah Campbell🇺🇸University of Utah
- Chris R. Stockmann🇺🇸University of Utah
- Casey R. Tak🇺🇸University of Utah
- Katherine Schoen🇺🇸University of Utah
- Erin Clark🇺🇸University of Utah
- Michael Walter Varner🇺🇸Intermountain Healthcare; University of Utah
- Michael G. Spigarelli🇺🇸University of Utah
- Catherine M.T. Sherwin🇺🇸 · autor de correspondenciaUniversity of Utah
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study sought to assess the pharmacokinetic (PK) changes of caffeine and its CYP1A2 metabolites across the 3 trimesters of pregnancy. A prospective, multicenter PK study was conducted among 59 pregnant women (93.2% white) who were studied once during a trimester. One beverage with 30-95 mg caffeine was consumed, and a blood/urine sample was collected within 1 hour postingestion. Concentrations of caffeine and its primary metabolites were quantified from serum and urine by LC-MS/MS. There was a significant increase in dose-normalized caffeine serum and urine concentrations between the first and third trimesters (P < .05 and P < .01, respectively). Normalized theophylline concentrations also increased significantly in the third trimester in serum (P < .001) and in urine (P < .05). The caffeine urine/serum concentration ratio also increased in the last trimester (P < .05). No significant difference was found in normalized paraxanthine or theobromine concentrations. This study identified decreased caffeine metabolism and an increase in the active metabolite theophylline concentrations during pregnancy, especially in the third trimester, revealing evidence of the large role that pregnancy plays in influencing caffeine metabolism.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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