Effects of short-term walnut consumption on human microvascular function and its relationship to plasma epoxide content
Holt RR, Yim SJ, Shearer GC, Hackman RM, Djurica D, Newman JW, Shindel AW, Keen CL
The Journal of nutritional biochemistry · 24 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of California, Davis
Según 1 financiador declarado.
Publicación
- Publicado
- 2015-08-03 · J Nutr Biochem · vol. 26 · número 12 · págs. 1458–1466
- Editorial
- Elsevier BV
- Citado
- 33 citas · más que el 86% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Fatty Acid Research and Health · Eicosanoids and Hypertension Pharmacology
- Palabras clave
- walnut consumption, microvascular function, reactive hyperemia index, cytochrome P450 metabolites, fatty acid epoxides, 14,15-epoxyeicosatrienoic acid, arachidonic acid, hydroxyeicosatetraenoic acids, serum lipids, dietary fatty acids
- MeSH
- microcirculation, humans, juglans, nuts, hyperemia, hypercholesterolemia, epoxy compounds, lipids, fatty acids, arachidonic acid, linoleic acid, lipoproteins, diet, aged, middle aged, female, cholesterol, ldl, cholesterol, hdl, oxylipins, diet, high-fat
8 autores
- Roberta R. Holt🇺🇸 · autor de correspondenciaUniversity of California, Davis
- Sun Jung Yim🇺🇸University of California, Davis
- Gregory C. Shearer🇺🇸Pennsylvania State University; University of South Dakota; Sanford Research
- Robert M. Hackman🇺🇸University of California, Davis
- Dragana Djurica🇺🇸University of California, Davis
- John W. I. Newman🇺🇸United States Department of Agriculture; Western Human Nutrition Research Center; University of California, Davis
- Alan W. Shindel🇺🇸University of California Davis Medical Center
- Carl L. Keen🇺🇸University of California Davis Medical Center; University of California, Davis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Improved vascular function after the incorporation of walnuts into controlled or high-fat diets has been reported; however, the mechanism(s) underlying this effect of walnuts is(are) poorly defined. The objective of the current study was to evaluate the acute and short-term effects of walnut intake on changes in microvascular function and the relationship of these effects to plasma epoxides, the cytochrome-P450-derived metabolites of fatty acids. Thirty-eight hypercholesterolemic postmenopausal women were randomized to 4 weeks of 5 g or 40 g of daily walnut intake. All outcomes were measured after an overnight fast and 4 h after walnut intake. Microvascular function, assessed as the reactive hyperemia index (RHI), was the primary outcome measure, with serum lipids and plasma epoxides as secondary measures. Compared to 5 g of daily walnut intake, consuming 40 g/d of walnuts for 4 weeks increased the RHI and Framingham RHI. Total cholesterol and low- and high-density cholesterol did not significantly change after walnut intake. The change in RHI after 4 weeks of walnut intake was associated with the change in the sum of plasma epoxides (r=0.65, P=.002) but not with the change in the sum of plasma hydroxyeicosatetraenoic acids. Of the individual plasma epoxides, arachidonic-acid-derived 14(15)-epoxyeicosatrienoic acid was most strongly associated with the change in microvascular function (r=0.72, P<.001). These data support the concept that the intake of walnut-derived fatty acids can favorably affect plasma epoxide production, resulting in improved microvascular function.
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