Nut consumption for the primary prevention of cardiovascular disease
Martin N, Germanò R, Hartley L, Adler AJ, Rees K
The Cochrane database of systematic reviews · 16 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- National Institute for Health and Care Research (WMCLAHRC-2014-1); National Institute for Health and Care Research (10/4001/13)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2015-09-28 · Cochrane Database Syst Rev · vol. 2015 · número 9 · pág. CD011583
- Editorial
- Elsevier BV
- Citado
- 24 citas · más que el 82% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 160 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nuts composition and effects · Peanut Plant Research Studies · Botany, Ecology, and Taxonomy Studies
- Palabras clave
- Medicine, CINAHL, Clinical trial, MEDLINE, Randomized controlled trial, Meta-analysis, Disease, Relative risk, Data extraction, Family medicine, Environmental health, Psychological intervention, Internal medicine, Confidence interval, Psychiatry
- MeSH
- humans, nuts, cardiovascular diseases, lipids, primary prevention, blood pressure, randomized controlled trials as topic
5 autores
- Nicole Martin🇬🇧Farr Institute; University College London
- Roberta Germanò🇮🇹University of Naples Federico II
- Louise Hartley🇬🇧University of Warwick
- Alma J Adler🇬🇧London School of Hygiene & Tropical Medicine
- Karen Rees🇬🇧University of Warwick
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Nuts contain a number of nutritional attributes which may be cardioprotective. A number of epidemiological studies have shown that nut consumption may have a beneficial effect on people who have cardiovascular disease (CVD) risk factors. However, results from randomised controlled trials (RCTs) are less consistent.
Objectives
To determine the effectiveness of nut consumption for the primary prevention of CVD.
Search methods
We searched the following electronic databases: the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, Web of Science Core Collection, CINAHL, Database of Abstracts of Reviews of Effects (DARE), Health Technology Assessment Database (HTA) and Health Economics Evaluations Database (HEED) up to 30 July 2015. We searched trial registers and reference lists of reviews for further studies. We did not apply any language restrictions.
Selection criteria
We included RCTs of dietary advice to increase nut consumption or provision of nuts to increase consumption lasting at least three months and including healthy adults or adults at moderate and high risk of CVD. The comparison group was no intervention or minimal intervention. The outcomes of interest were CVD clinical events and CVD risk factors.
Data collection and analysis
Two review authors independently selected trials for inclusion, abstracted the data and assessed the risk of bias in included trials.
Main results
We included five trials (435 participants randomised) and one ongoing trial. One study is awaiting classification. All trials examined the provision of nuts to increase consumption rather than dietary advice. None of the included trials reported on the primary outcomes, CVD clinical events, but trials were small and short term. All five trials reported on CVD risk factors. Four of these trials provided data in a useable format for meta-analyses, but heterogeneity precluded meta-analysis for most of the analyses. Overall trials were judged to be at unclear risk of bias.There were variable and inconsistent effects of nut consumption on CVD risk factors (lipid levels and blood pressure). Three trials monitored adverse events. One trial reported an allergic reaction to nuts and three trials reported no significant weight gain with increased nut consumption. None of the included trials reported on other secondary outcomes, occurrence of type 2 diabetes as a major risk factor for CVD, health-related quality of life and costs.
Authors' conclusions
Currently there is a lack of evidence for the effects of nut consumption on CVD clinical events in primary prevention and very limited evidence for the effects on CVD risk factors. No conclusions can be drawn and further high quality longer term and adequately powered trials are needed to answer the review question.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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