Can Creatine Supplementation Improve Body Composition and Objective Physical Function in Rheumatoid Arthritis Patients? A Randomized Controlled Trial
Wilkinson TJ, Lemmey AB, Jones JG, Sheikh F, Ahmad YA, Chitale S, Maddison PJ, O'brien TD
Arthritis care & research · 34 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Betsi Cadwaladr University Health Board
- Universidad u hospital
- Betsi Cadwaladr University Health Board Small Grants Committee
Según 2 financiadores declarados.
Publicación
- Publicado
- 2015-09-28 · Arthritis Care Res (Hoboken) · vol. 68 · número 6 · págs. 729–737
- Editorial
- Wiley
- Citado
- 58 citas · más que el 86% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nutrition and Health in Aging · Exercise and Physiological Responses · Rheumatoid Arthritis Research and Therapies
- Palabras clave
- Medicine, Lean body mass, Creatine, Rheumatoid arthritis, Wasting, Placebo, Internal medicine, Bioelectrical impedance analysis, Cachexia, Randomized controlled trial, Creatine Monohydrate, Isometric exercise, Sarcopenia, Grip strength, Physical therapy, Gastroenterology, Body mass index, Body weight, Pathology
- MeSH
- muscle, skeletal, humans, arthritis, rheumatoid, creatine, absorptiometry, photon, double-blind method, dietary supplements, adult, aged, middle aged, female, male, muscle strength
8 autores
- Thomas James Wilkinson🇬🇧Bangor University
- ANDREW B. LEMMEY🇬🇧Bangor University
- Jeremy G. Jones🇬🇧Bangor University
- Fazal Sheikh🇬🇧Bangor University
- Yasmeen A. Ahmad🇬🇧Bangor University
- Sarang Chitale🇬🇧Bangor University
- Peter J. Maddison🇬🇧Bangor University
- Thomas D. O’Brien🇬🇧Liverpool John Moores University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Rheumatoid cachexia (muscle wasting) in rheumatoid arthritis (RA) patients contributes to substantial reductions in strength and impaired physical function. The objective of this randomized controlled trial was to investigate the effectiveness of oral creatine (Cr) supplementation in increasing lean mass and improving strength and physical function in RA patients.
Methods
In a double-blind design, 40 RA patients were randomized to either 12 weeks' supplementation of Cr or placebo. Body composition (dual x-ray absorptiometry and bioelectrical impedance spectroscopy [BIS]), strength, and objectively assessed physical function were measured at baseline, day 6, week 12, and week 24. Data analysis was performed by analysis of covariance.
Results
Cr supplementation increased appendicular lean mass (ALM; a surrogate measure of muscle mass) by mean ± SE 0.52 ± 0.13 kg (P = 0.004 versus placebo), and total LM by 0.60 ± 0.37 kg (P = 0.158). The change in LM concurred with the gain in intracellular water (0.64 ± 0.22 liters; P = 0.035) measured by BIS. Despite increasing ALM, Cr supplementation, relative to placebo, failed to improve isometric knee extensor strength (P = 0.408), handgrip strength (P = 0.833), or objectively assessed physical function (P = 0.335-0.764).
Conclusion
In patients with RA, Cr supplementation increased muscle mass, but not strength or objective physical function. No treatment-related adverse effects were reported, suggesting that Cr supplementation may offer a safe and acceptable adjunct treatment for attenuating muscle loss; this treatment may be beneficial for patients experiencing severe rheumatoid cachexia.
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