Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial
Hollis BW, Wagner CL, Howard CR, Ebeling M, Shary JR, Smith PG, Taylor SN, Morella K, Lawrence RA, Hulsey TC
Pediatrics · 159 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NIGMS NIH HHS
- Gobierno
- NICHD NIH HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Institute of General Medical Sciences (U54-GM-104942); National Institutes of Health (UL1TR000062); National Center for Research Resources (RR-01070); National Center for Research Resources (M01 RR001070); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD043921)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2015-09-29 · Pediatrics · vol. 136 · número 4 · págs. 625–634
- Editorial
- American Academy of Pediatrics
- Citado
- 246 citas · más que el 100% de estudios similares · 19.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Breastfeeding Practices and Influences · Vitamin K Research Studies
- Palabras clave
- vitamin D3 supplementation, lactation, breast-fed infants, maternal vitamin D deficiency, 25-hydroxyvitamin D, exclusive breastfeeding, urinary calcium/creatinine ratio
- MeSH
- humans, vitamin d deficiency, cholecalciferol, vitamins, double-blind method, breast feeding, lactation, dietary supplements, adolescent, adult, middle aged, infant, female, young adult, maternal health
10 autores
- Bruce W. Hollis🇺🇸Medical University of South Carolina
- Carol L. Wagner🇺🇸Medical University of South Carolina
- Cynthia Ruth Howard🇺🇸University of Rochester Medicine; University of Rochester
- Myla D. Ebeling🇺🇸West Virginia University
- Judy R. Shary🇺🇸Medical University of South Carolina
- Pamela G. Smith🇺🇸Medical University of South Carolina
- Sarah N. Taylor🇺🇸Medical University of South Carolina
- Kristen Morella🇺🇸West Virginia University
- Ruth A. Lawrence🇺🇸University of Rochester Medicine; University of Rochester
- Thomas C. Hulsey🇺🇸West Virginia University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Compare effectiveness of maternal vitamin D3 supplementation with 6400 IU per day alone to maternal and infant supplementation with 400 IU per day.
Methods
Exclusively lactating women living in Charleston, SC, or Rochester, NY, at 4 to 6 weeks postpartum were randomized to either 400, 2400, or 6400 IU vitamin D3/day for 6 months. Breastfeeding infants in 400 IU group received oral 400 IU vitamin D3/day; infants in 2400 and 6400 IU groups received 0 IU/day (placebo). Vitamin D deficiency was defined as 25-hydroxy-vitamin D (25(OH)D) <50 nmol/L. 2400 IU group ended in 2009 as greater infant deficiency occurred. Maternal serum vitamin D, 25(OH)D, calcium, and phosphorus concentrations and urinary calcium/creatinine ratios were measured at baseline then monthly, and infant blood parameters were measured at baseline and months 4 and 7.
Results
Of the 334 mother-infant pairs in 400 IU and 6400 IU groups at enrollment, 216 (64.7%) were still breastfeeding at visit 1; 148 (44.3%) continued full breastfeeding to 4 months and 95 (28.4%) to 7 months. Vitamin D deficiency in breastfeeding infants was greatly affected by race. Compared with 400 IU vitamin D3 per day, 6400 IU/day safely and significantly increased maternal vitamin D and 25(OH)D from baseline (P < .0001). Compared with breastfeeding infant 25(OH)D in the 400 IU group receiving supplement, infants in the 6400 IU group whose mothers only received supplement did not differ.
Conclusions
Maternal vitamin D supplementation with 6400 IU/day safely supplies breast milk with adequate vitamin D to satisfy her nursing infant's requirement and offers an alternate strategy to direct infant supplementation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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