Financiado en parte por Else Kröner-Fresenius-Stiftung, Else-Kröner Fresenius Stiftung
Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment
Köbe T, Witte AV, Schnelle A, Lesemann A, Fabian S, Tesky VA, Pantel J, Flöel A
NeuroImage · 92 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Deutsche Forschungsgemeinschaft
- Gobierno
- Bundesministerium für Bildung und Forschung
- Empresa
- Else Kröner-Fresenius-Stiftung
- Empresa
- Else-Kröner Fresenius Stiftung
- Subvenciones
- Deutsche Forschungsgemeinschaft (Fl 379-10/1); Deutsche Forschungsgemeinschaft (Fl‐379‐8/1); Bundesministerium für Bildung und Forschung (01GY1144); Deutsche Forschungsgemeinschaft (DFG EXC-257); Deutsche Forschungsgemeinschaft (Fl 379-11/1); Bundesministerium für Bildung und Forschung (FKZ0315673A); Else Kröner-Fresenius-Stiftung (2009-141); Else Kröner-Fresenius-Stiftung (2011-119); Bundesministerium für Bildung und Forschung (01EO0801); Bundesministerium für Bildung und Forschung (01GQ1424A); Bundesministerium für Bildung und Forschung (01GQ1420B)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2015-10-03 · Neuroimage · vol. 131 · págs. 226–238
- Editorial
- Elsevier BV
- Citado
- 132 citas · más que el 98% de estudios similares · 8.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 127 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dementia and Cognitive Impairment Research · Fatty Acid Research and Health · Alzheimer's disease research and treatments
- Palabras clave
- omega-3 fatty acids, aerobic exercise, cognitive stimulation, mild cognitive impairment, gray matter volume, Alzheimer's disease, brain atrophy, homocysteine, vascular risk factors, inflammation, older adults, cognitive function
- MeSH
- cerebral cortex, humans, fatty acids, omega-3, organ size, treatment outcome, combined modality therapy, exercise therapy, diet therapy, administration, oral, dietary supplements, aged, aged, 80 and over, middle aged, female, male, cognitive dysfunction, cognitive behavioral therapy
8 autores
- Theresa Köbe🇩🇪 · autor de correspondenciaNeuroCure Cluster of Excellence; Charité - Universitätsmedizin Berlin
- A. Veronica Witte🇩🇪Max Planck Institute for Human Cognitive and Brain Sciences; NeuroCure Cluster of Excellence; Charité - Universitätsmedizin Berlin; Leipzig University
- Ariane Schnelle🇩🇪NeuroCure Cluster of Excellence; Charité - Universitätsmedizin Berlin
- Anne Lesemann🇩🇪NeuroCure Cluster of Excellence; Charité - Universitätsmedizin Berlin
- Sonja Fabian🇩🇪NeuroCure Cluster of Excellence; Charité - Universitätsmedizin Berlin
- Valentina Antonia Tesky🇩🇪Goethe University Frankfurt
- Johannes Pantel🇩🇪Goethe University Frankfurt
- Agnes Flöel🇩🇪 · autor de correspondenciaStiftung Charité; NeuroCure Cluster of Excellence; Center for Stroke Research Berlin; Charité - Universitätsmedizin Berlin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Previous studies in older adults suggested beneficial effects of omega-3 fatty acid (FA) supplementation, aerobic exercise, or cognitive stimulation on brain structure and function. However, combined effects of these interventions in patients suffering from mild cognitive impairment (MCI) are unknown. Using a randomized interventional design, we evaluated the effect of combined omega-3 FA supplementation, aerobic exercise and cognitive stimulation (target intervention) versus omega-3 FA supplementation and non-aerobic exercise (control intervention) on cognitive function and gray matter volume in patients with MCI. Moreover, we analyzed potential vascular, metabolic or inflammatory mechanisms underlying these effects. Twenty-two MCI patients (8 females; 60-80years) successfully completed six months of omega-3 FA intake, aerobic cycling training and cognitive stimulation (n=13) or omega-3 FA intake and non-aerobic stretching and toning (n=9). Before and after the interventions, cognitive performance, magnetic resonance imaging of the brain at 3T (n=20), intima-media thickness of the internal carotid artery and serum markers of glucose control, lipid and B-vitamin metabolism, and inflammation were assessed. Intervention-related changes in gray matter volume of Alzheimer's disease (AD)-related brain regions, i.e., frontal, parietal, temporal and cingulate cortex were examined using voxel-based morphometry of high resolution T1-weighted images. After the intervention period, significant differences emerged in brain structure between groups: Gray matter volume decreased in the frontal, parietal and cingulate cortex of patients in the control intervention, while gray matter volume in these areas was preserved or even increased after the target intervention. Decreases in homocysteine levels in the target intervention group were associated with increases in gray matter volume in the middle frontal cortex (p=0.010). No significant differences in cognitive performance or other vascular, metabolic and inflammatory parameters were observed between groups. This pilot study provides preliminary evidence that omega-3 FA intake combined with aerobic exercise and cognitive stimulation prevents atrophy in AD-related brain regions in MCI patients, compared to omega-3 FA intake plus the control condition of stretching and toning. These promising findings should now be validated in a larger interventional trial.
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