Linoleic acid and breast cancer risk: a meta-analysis
Zhou Y, Wang T, Zhai S, Li W, Meng Q
Public health nutrition · 41 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-10-05 · Public Health Nutr · vol. 19 · número 8 · págs. 1457–1463
- Editorial
- Cambridge University Press
- Citado
- 66 citas · más que el 43% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Cancer, Lipids, and Metabolism · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Linoleic acid, Breast cancer, Medicine, Prospective cohort study, Internal medicine, Relative risk, Meta-analysis, Cohort study, Lower risk, Cancer, Conjugated linoleic acid, Fatty acid, Endocrinology, Gastroenterology, Chemistry, Confidence interval, Biochemistry
- MeSH
- humans, breast neoplasms, linoleic acid, diet, risk factors, female
5 autores
- Yunping Zhou🇨🇳The Fourth People's Hospital of Zibo City; Shandong Center for Disease Control and Prevention
- Tao Wang🇨🇳The Fourth People's Hospital of Zibo City; Shandong Center for Disease Control and Prevention
- Shenyong Zhai🇨🇳The Fourth People's Hospital of Zibo City; Shandong Center for Disease Control and Prevention
- Wei Li🇨🇳The Fourth People's Hospital of Zibo City; Shandong Center for Disease Control and Prevention
- Qiang Meng🇨🇳 · autor de correspondenciaThe Fourth People's Hospital of Zibo City; Shandong Center for Disease Control and Prevention
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Prior studies on linoleic acid, the predominant n-6 fatty acid, and breast cancer risk have generated inconsistent results. We performed a meta-analysis to summarize the evidence regarding the relationship of dietary and serum linoleic acid with breast cancer risk.
Design
Pertinent studies were identified by a search of PubMed and EMBASE. The fixed- or random-effect pooled measure was selected based on between-study heterogeneity.
Results
Eight prospective cohort studies and four prospective nested case-control studies, involving 10 410 breast cancer events from 358 955 adult females across different countries, were included in present study. Compared with the lowest level of linoleic acid, the pooled relative risk (RR; 95 % CI) of breast cancer was 0·98 (0·93, 1·04) for the highest level of linoleic acid. The pooled RR (95 % CI) for dietary and serum linoleic acid were 0·99 (0·92, 1·06) and 0·98 (0·88, 1·08), respectively. The RR (95 % CI) of breast cancer was 0·97 (0·91, 1·04), 0·95 (0·85, 1·07), 0·96 (0·86, 1·07), 0·98 (0·87, 1·10) and 0·99 (0·85, 1·14) for linoleic acid intake of 5, 10, 15, 20 and 25 g/d, respectively. The risk of breast cancer decreased by 1 % (RR=0·99; 95 % CI 0·93, 1·05) for every 10 g/d increment in linoleic acid intake.
Conclusions
This meta-analysis indicated that both dietary linoleic acid intake and serum linoleic acid level were associated with decreased risk of breast cancer, although none of the associations were statistically significant. Further investigations are warranted.
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