Vitamin D Deficiency Increases the Risk of Gestational Diabetes Mellitus: A Meta-Analysis of Observational Studies
Zhang MX, Pan GT, Guo JF, Li BY, Qin LQ, Zhang ZL
Nutrients · 114 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Chinese Nutrition Society
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Natural Science Foundation of Jiangsu Province
- Gobierno
- Jiangsu Natural Science Foundation
- Subvenciones
- National Natural Science Foundation of China (81372979); Natural Science Foundation of Jiangsu Province (BK2012619); National Natural Science Foundation of China (81372981，81372979)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-10-01 · Nutrients · vol. 7 · número 10 · págs. 8366–8375
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 176 citas · más que el 94% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Gestational Diabetes Research and Management · Birth, Development, and Health
- Palabras clave
- vitamin D deficiency, gestational diabetes mellitus, 25-hydroxyvitamin D, serum vitamin D levels, pregnancy, vitamin D supplementation, risk factors
- MeSH
- humans, diabetes, gestational, vitamin d deficiency, vitamin d, odds ratio, risk factors, case-control studies, pregnancy, dietary supplements, medline, adult, female
6 autores
- Mengxi Zhang🇨🇳Soochow University
- Guo-Tao Pan🇨🇳Soochow University
- Jian-Fen Guo🇨🇳Soochow University
- Bingyan Li🇨🇳Soochow University
- Li‐Qiang Qin🇨🇳Soochow University
- Zengli Zhang🇨🇳Soochow University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The results investigating the relationship between vitamin D levels and gestational diabetes mellitus (GDM) are inconsistent. Thus, we focused on evaluating the association of vitamin D deficiency with GDM by conducting a meta-analysis of observed studies. A systematic literature search was conducted via PubMed, MEDLINE, and Cochrane library to identify eligible studies before August 2015. The meta-analysis of 20 studies including 9209 participants showed that women with vitamin D deficiency experienced a significantly increased risk for developing GDM (odds ratio (OR) = 1.53; 95% confidence intervals (CI), 1.33, 1.75) with a little heterogeneity (I² = 16.20%, p = 0.252). A noteworthy decrease of 4.93 nmol/L (95% CI, -6.73, -3.14) in serum 25(OH)D was demonstrated in the participants with GDM, and moderate heterogeneity was observed (I² = 61.40%, p = 0.001). Subgroup analysis with study design showed that there were obvious heterogeneities in nested case-control studies (I² > 52.5%, p < 0.07). Sensitivity analysis showed that exclusion of any single study did not materially alter the overall combined effect. In summary, the evidence from this meta-analysis indicates a consistent association between vitamin D deficiency and an increased risk of GDM. However, well-designed randomized controlled trials are needed to elicit the clear effect of vitamin D supplementation on prevention of GDM.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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